Dept. of Genetics International Publications

2012 – 2013 Publications

  1. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St  George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer’s disease. N Engl J Med. 2013 Jan 10;368(2):117-27.
  2. Onat A, Can G, Ornek E, Ayhan E, Erginel-Ünaltuna N, Murat SN. High Serum Apolipoprotein E Determines Hypertriglyceridemic Dyslipidemias, Coronary Disease  and ApoA-I Dysfunctionality. Lipids. 2013 Jan;48(1):51-61.
  3. Guclu-Geyik F, Onat A, Coban N, Komurcu-Bayrak E, Sansoy V, Can G, Erginel-Unaltuna N. Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women. Mol Biol Rep. 2012 Dec;39(12):10907-14.
  4. Komurcu-Bayrak E, Ozsait B, Erginel-Unaltuna N. Isolation and analysis of genes mainly expressed in adult mouse heart using subtractive hybridization cDNA  library. Mol Biol Rep. 2012 Aug;39(8):8065-74.
  5.  Lohmann E, Guerreiro RJ, Erginel-Unaltuna N, Gurunlian N, Bilgic B, Gurvit H,  Hanagasi HA, Luu N, Emre M, Singleton A. Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients. Neurobiol Aging. 2012 Aug;33(8):1850.e17-27.
  6. Hannon M, Lohan F, Erbilgin Y, Sayitoglu M, O’Hagan K, Mills K, Ozbek U, Keeshan K. Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. Br J Haematol. 2012 Jul 6.
  7. Yavuz EN, Ozdemir O, Catal S, Bebek N, Ozbek U, Baykan B. Bromodomain-Containing Protein 2 gene in photosensitive epilepsy. Seizure. 2012 Jul 3.
  8. Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K. Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray Cross-Complementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange Frequency in Patients with Chronic Lymphocytic Leukemia. Genetic Testing and Molecular Biomarkers Volume: 16 Issue: 4 Pages: 287-291. APR 2012.
  9. Vural B, Yakar F, Derin D, Saip P, Yakar A, Demirkan A, Karabulut A, Ugurel E, Cine N, Kilicaslan Z, Tüzün E, Ozbek U. Evaluation of Glutathione S-Transferase P1 Polymorphisms (Ile105Val and Ala114Val) in Patients with Small Cell Lung Cancer. Genet Test Mol Biomarkers. 2012 Feb 17.

           10. EPICURE Consortium, Leu C, de Kovel CG, Zara F, Striano P, Pezzella M,       Robbiano A, Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuss-Lie AA, Hallman K, Kunz WS, Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A, Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U, Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies. Epilepsia. 2012 Feb;53(2):308-18.

11. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia.Leuk Res. 2012 Jan;36(1):87-92.

12. Gialluisi A, Pippucci T, Anikster Y, Ozbek U, Medlej-Hashim M, Mégarbané A, Romeo G.Estimating the allele frequency of autosomal recessive disorders through mutational records and consanguinity: the Homozygosity Index (HI).Ann Hum Genet. 2012 Mar;76(2):159-67.

13. Atalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS.,11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genet Mol Res. 2012 Aug 31;11(3):3122-32.

14. Erdağ E, Tüzün E, Uğurel E, Cavuş F, Sehitoğlu E, Giriş M, Vural B, Eraksoy M, Akman-Demir G., Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse. Inflamm Res. 2012 Sep;61(9):927-30.

15. Uz B, Tatonyan SC, Sayitoglu M, Erbilgin Y, Ng OH, Buyukasik Y, Sayinalp N, Aksu S, Goker H, Ozcebe OI, Ozbek U, Haznedaroglu IC.Local hematopoietic renin-angiotensin system in myeloid versus lymphoid hematological neoplastic disorders. J Renin Angiotensin Aldosterone Syst. 2012 Nov 6.

16. Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol. 2012 Nov;10(11):e1001430.

17. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim AS, Yazici Z. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Cardiovasc Diabetol. 2012 Sep 25;11:115.

18. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim AS, Yazıcı Z. Mediastinal adipose tissue expresses a pathogenic profile of 11 β-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease. Cardiovasc Pathol. 2012 Sep 3.

19. EPICURE Consortium; EMINet Consortium, Steffens M, Leu C, Ruppert AK, Zara F, Striano P, Robbiano A, Capovilla G, Tinuper P, Gambardella A, Bianchi A, La Neve A, Crichiutti G, de Kovel CG, Kasteleijn-Nolst Trenité D, de Haan GJ, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Steinhoff BJ, Kleefuß-Lie AA, Kunz WS, Surges R, Elger CE, Muhle H, von Spiczak S, Ostertag P, Helbig I, Stephani U, Møller RS, Hjalgrim H, Dibbens LM, Bellows S, Oliver K, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Guipponi M, Malafosse A, Thomas P, Nabbout R, Baulac S, Leguern E, Guerrero R, Serratosa JM, Reif PS, Rosenow F, Mörzinger M, Feucht M, Zimprich F, Kapser C, Schankin CJ, Suls A, Smets K, De Jonghe P, Jordanova A, Caglayan H, Yapici Z, Yalcin DA, Baykan B, Bebek N, Ozbek U, Gieger C, Wichmann HE, Balschun T, Ellinghaus D, Franke A, Meesters C, Becker T, Wienker TF, Hempelmann A, Schulz H, Rüschendorf F, Leber M, Pauck SM, Trucks H, Toliat MR, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol Genet. 2012 Dec 15;21(24):5359-72.

20. Müge Sayitoğlu, Yücel Erbilgin, Özden Hatırnaz, İnci Yıldız, Tiraje Celkan, Sema Anak, Ömer Devecioğlu, Gönül Aydoğan, Serap Karaman, Nazan Sarper, Çetin Timur, Ümit Üre, Uğur Özbek. Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL). TJH pages 325-333.

21. Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic Alterations in the Members of WNT Pathway in Acute Leukemia. Leuk Lymphoma. 2012 Mar; 53(3): 508-10.

22. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gül A, Remmers EF, Kastner DL. Genome-wide association analysis identifies new susceptibility loci for Behçet’s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013 Jan 6.   

23. Cosan F, Emrence Z, Erbag G, Azakli H, Yilmazer B, Yazici A, Ekmekci SS, Abaci N, Ustek D, Cefle A. The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still’s disease. Rheumatol Int. 2012 Dec 27.

24. Gezer U, Ustek D, Yörüker EE, Cakiris A, Abaci N, Leszinski G, Dalay N, Holdenrieder S. Characterization of H3K9me3- and H4K20me3-associated circulating nucleosomal DNA by high-throughput sequencing in colorectal cancer. Tumour Biol. 2012 Oct 20.

25. Sogutcu E, Emrence Z, Arikan M, Cakiris A, Abaci N, Oner ET, Ustek D, Arga KY. Draft Genome Sequence of Halomonas smyrnensis AAD6T. J Bacteriol. 2012 Oct . 194(20):5690-1.

26. Kara B, Arıkan M, Maraş H, Abacı N, Cakıris A, Ustek D. Whole mitochondrial genome analysis of a family with NARP/MILS caused by m.8993T>C mutation in the MT-ATP6 gene. Mol Genet Metab. 2012 Jul 10.

27. Akyuz F, Besisik F, Ustek D, Ekmekçi C, Uyar A, Pinarbasi B, Demir K, Ozdil S, Kaymakoglu S, Boztas G, Mungan Z, Gul A. Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey. J Clin Gastroenterol. 2012 Jul 17.

28. Ozbek E, Polat EC, Ozcan L, Otunctemur A, Emrence Z, Ustek D. TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.J Obstet Gynaecol Res. 2012 Jul 6.

29. Sirma Ekmekci S, G Ekmekci C, Kandilci A, Gulec C, Akbiyik M, Emrence Z, Abaci N, Karakas Z, Agaoglu L, Unuvar A, Anak S, Devecioglu O, Ustek D, Grosveld G, Ozbek U. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Tumori. 2012 Mar . 98(2):252-6.

30. Ustek D, Sirma S, Gumus E, Arikan M, Cakiris A, Abaci N, Mathew J, Emrence Z, Azakli H, Cosan F, Cakar A, Parlak M, Kursun O. A genome-wide analysis of lentivector integration sites using targeted sequence capture and next generation sequencing technology. Infect Genet Evol. 2012 May 14.

31. Topcuoglu N, Keskin F, Ciftci S, Paltura C, Kulekci M, Ustek D, Kulekci G. Relationship between Oral Anaerobic Bacteria and Otitis Media with Effusion. Int J Med Sci. 2012 . 9(3):256-61.

32. Aruk T, Ustek D, Kursun O. A novel partial sequence alignment tool for finding large deletions. ScientificWorldJournal. 2012. 2012 :694813.

33. Bongiovanni A, Romancino DP, Campos Y, Paterniti G, Qiu X, Moshiach S, Di Felice V, Vergani N, Ustek D, d’Azzo A. Alix is a substrate of the Ozz-E3 ligase, and modulates actin remodeling in skeletal muscle. J Biol Chem. 2012 Feb 13.

34. Gumus E, Kursun O, Sertbas A, Ustek D Application of Canonical Correlation Analysis for Identifying Viral Integration Preferences. Bioinformatics. 2012 Jan 12.

35. Mahmut Parlak, Duran Ustek, Aziz Tanriseven. A novel method for covalent immobilization of dextransucrase. Journal of Molecular Catalysis B: Enzymatic 28 December 2012. 14.

2011 Publications

1. Coban N, Onat A, Guclu-Geyik F, Komurcu-Bayrak E, Sansoy V, Hergenc G, Can G, Erginel-Unaltuna N. Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) -482C>T polymorphism on triglyceride concentration in Turkish adults. Clin Chem Lab Med. 2011 Oct 18.

2. Hatemi AC, Güleç C, Cine N, Vural B, Hatırnaz O, Sayitoğlu M, Oztunç F, Saltık L, Kansız E, Erginel Ünaltuna N. Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism. Anadolu Kardiyol Derg. 2011 Jun;11(4):319-28.

3. Onat A, Erginel-Unaltuna N, Coban N, Ciçek G, Yüksel H. APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: interrelation and roles in predicting type-2 diabetes and coronary disease. Clin Biochem. 2011 Apr;44(5-6):391-6.

4. Komurcu-Bayrak E, Onat A, Yuzbasiogullari B, Mononen N, Laaksonen R, Kähönen M, Hergenc G, Lehtimäki T, Erginel-Unaltuna N. The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks. Metabolism. 2011 May;60(5):655-63.

5. Adas G, Percem A, Adas M, Kemik O, Arikan S, Ustek D, Cakiris A, Abaci N, Kemik AS, Kamali G, Karahan S, Akcakaya A, Karatepe O. VEGF-A and FGF gene therapy accelerate healing of ischemic colonic anastomoses (experimental study). Int J Surg. 2011;9(6):467-71. Epub 2011 May 27.

6. Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K. Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray Cross-Complementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange Frequency in Patients with Chronic Lymphocytic Leukemia. Genet Test Mol Biomarkers. 2011 Nov 22.

7.  Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, Kamali G, Eryasar B, Ustek D. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2011 Jan;396(1):115-26. Epub 2010 Oct 17.

8. Abaci N, Cosan F, Gulec C, Azakli H, Emrence Z, Sirma-Ekmekci S, Cakiris A, Oku B; Ustek D. HYPOXIA INDUCES ERYTHROPOIETIN RECEPTOR EXPRESSION ON K562 CELL LINE BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT AUG:2011: 25(3): 2508-2512   DOI: 10.5504/BBEQ.2011.0061

9. Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B.Pancreas-Specific Deletion of Prox1 Affects Development and Disrupts Homeostasis of the Exocrine Pancreas. Gastroenterology. 2011 Dec 13.

10. Sema Sırma Ekmekci, Cumhur G. Ekmekci, Ayten Kandilci, Çagrı Güleç, Meral Akbıyık, Zeliha Emrence, Neslihan Abacı, Zeynep Karakaş, Leyla Ağaoğlu, Ayşegül Ünüvar, Sema Anak, Ömer Devecioğlu, Duran Ustek, Gerard Grosveld, Uğur Özbek. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Tumori (kabul edildi).

11. Ostergaard M, Nyvold CG, Jovanovic JV, Andersen MT, Kairisto V, Morgan YG, Tobal K, Pallisgaard N, Ozbek U, Pfeifer H, Schnittger S, Grubach L, Larsen JK, Grimwade D, Hokland P. Development of standardized approaches to reporting of minimal residual disease data using a reporting software package designed within the European LeukemiaNet. Leukemia. 2011 Jul;25(7):1168-73. doi: 10.1038/leu.2011.69. Epub 2011 Apr 15.

12. Gormez S, Demirkan A, Atalar F, Caynak B, Erdim R, Sozer V, Gunay D, Akpinar B, Ozbek U, Buyukdevrim AS. Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease. Intern Med. 2011;50(8):805-10. Epub 2011 Apr 15.

13. Saip R, Sen F, Vural B, Ugurel E, Demirkan A, Derin D, Eralp Y, Camlica H, Ustuner Z, Ozbek U. Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients. J BUON. 2011 Apr-Jun;16(2):241-6.

14. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia. Leuk Res. 2011 Aug 1.

15. Burçak Vural, Elif Uğurel, Erdem Tuzun, Murat Kurtuncu, Luigi Zuliani, Filiz  Çavuş, Sema İçöz , Ece Erdağ, Ahmet Gul, Ali O. Gure, Angela Vincent, Uğur Özbek, Mefkure Eraksoy, Gulşen Akman-Demir. Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet’s disease. Journal of Neuroimmunology 239 (2011) 91–97.

16. Yildirim Y., Orhan EK., Iseri SAU., Serdaroglu-Oflazer P., Kara B., Solakoglu, S., Tolun A. A frameshift mutation of ERLIN2 in recessive intellectual disability, motor dysfunction and multiple joint contractures. HUMAN MOLECULAR GENETICS Volume: 20   Issue: 10   Pages: 1886-1892  Published: MAY 15 2011

17. Alessandro Gialluisi, Tommaso Pippucci, Yair Anikster, Ugur Ozbek, Myrna Medlej-Hashim, Andre Me´garbane  and Giovanni Romeo. Estimating the Allele Frequency of Autosomal Recessive Disorders through Mutational Records and Consanguinity: The Homozygosity Index (HI). Annals of Human Genetics (2011) 00,1–9.

18. A. E. Eskazan, T. Soysal, Y. Erbilgin, U. Ozbek, B. Ferhanoglu. Chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutations are resistant to dasatinib: Is that true for all the patients? Leukemia Research, 21 May 2011.

19. Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic Alterations in the Members of WNT Pathway in Acute Leukemia. Leuk Lymphoma. 2011 Sep 9.

2009-2010 Publications

1. Ozsait B, Komurcu-Bayrak E, Levula M, Erginel-Unaltuna N, Kähönen M, Rai M, Lehtimäki T, Laaksonen R., Niemann-Pick type C fibroblasts have a distinct microRNA profile related to lipid metabolism and certain cellular components. Biochem Biophys Res Commun. 2010 Nov 12. [Epub ahead of print]

2. Onat A, Erginel-Unaltuna N, Coban N, Ciçek G, Yüksel H. APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: Interrelation and roles in predicting type-2 diabetes and coronary disease. Clin Biochem. 2010 Dec 23. [Epub ahead of print] PubMed PMID: 21185820.

3. Komurcu-Bayrak E, Onat A, Yuzbasiogullari B, Mononen N, Laaksonen R, Kähönen M, Hergenc G, Lehtimäki T, Erginel-Unaltuna N., The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks., Metabolism. 2010 Aug 17. [Epub ahead of print]PMID: 20723945 [PubMed – as supplied by publisher]Related citations

4. Gözü A, Poda M, Taşkin EI, Turgut H, Erginel-Unaltuna N, Doğruman H, Ozsoy Z., Pretreatment with octreotide modulates iNOS gene expression, mimics surgical delay, and improves flap survival., Ann Plast Surg. 2010 Aug;65(2):245-9.

5. Onat A, Kömürcü-Bayrak E, Can G, Küçükdurmaz Z, Hergenç G, Erginel-Unaltuna N., Apolipoprotein A-I positively associated with diabetes in women independently of apolipoprotein E genotype and apolipoprotein B levels., Nutrition. 2010 Oct;26(10):975-80.

6. Abaci N, Güleç C, Bayrak F, Kömürcü Bayrak E, Kahveci G, Erginel Unaltuna N.The variations of BOP gene in hypertrophic cardiomyopathy., Anadolu Kardiyol Derg. 2010;10(4):303-9.

7. Gurses C, Ekizoglu O, Orhan N, Ustek D, Arican N, Ahishali B, Elmas I, Kucuk M, Bilgic B, Kemikler G, Kalayci R, Karadeniz A, Kaya M. Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia. Brain Res. 2009 Jul 24;1281:71-83. Epub 2009 May 21. PMID: 19464270.

8. Coşan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoğlu F, Saruhan-Direskeneli G, Ustek D, Gül A. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçets disease. Clin Rheumatol. 2009 Dec;28(12):1385-8. Epub 2009 Aug 21. PMID: 19693643.

9. Cosan F, Yazici A, Yılmazer B, Gul A, Ustek D, Cefle A. A novel TNFRSF1 gene mutation in a Turkish family: a report of three cases. Clin Rheumatol. 2010 Jun 10.PMID: 20532935.

10. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, OShea J, Wallace GR, Gadina M, Kastner DL, Gül A. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçets disease. Nat Genet. 2010 Aug;42(8):698-702. 2010 Jul 11. PMID: 20622878.

11. Cosan F, Ustek D, Oku B, Duymaz-Tozkir J, Cakiris A, Abaci N, Ocal L, Aral O, Gül A. Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. Arthritis Rheum. 2010 Nov;62(11):3232-6. doi: 10.1002/art.27683. PMID: 20669279.

12. Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, Kamali G, Eryasar B, Ustek D. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2010 Oct 17. PMID: 20953879.

13. Erbilgin Y, Sayitoglu M, Hatirnaz O, Dogru O, Akcay A, Tuysuz G, Celkan T, Aydogan G, Salcioglu Z, Timur C, Yuksel-Soycan L, Ure U , Anak S, Agaogl S, Devecioglu O, Yildiz I, Ozbek U, Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. Disease Markers 28 (2010) 1–8

14. Atalar F, Tevfik Acuner T, Cine N, Oncu F, Yesilbursa D, Ozbek U, Turkcan S.Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study. Behav Brain Funct. 2010 May 28;6(1):27

15. Vural B, Demirkan A, Ugurel E, Kalaylioglu-Wheeler Z, Esen BA, Gure AO, Gül A, Ozbek U. Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behçets disease. Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S67-72.

16. Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK, Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U. Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia. Genet Test Mol Biomarkers. 2009 Oct;13(5):599-602.

17. Baccarani M, Rosti G, Castagnetti F, Haznedaroglu I, Porkka K, Abruzzese E, Alimena G, Ehrencrona H, Hjorth-Hansen H, Kairisto V, Levato L, Martinelli G, Nagler A, Nielsen JL, Ozbek U, Palandri F, Palmieri F, Pane F, Rege-Cambrin G, Russo D, Specchia G, Testoni N, Weiss-Bjerrum O, Saglio G, Simonsson B. A comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of patients with high risk, Philadelphia-positive, chronic myeloid leukaemia: a European LeukemiaNet study. Blood. 2009 May 7;113(19):4497-504

18. Muge Sayitoglu, Ibrahim C. Haznedaroglu, Ozden Hatirnaz, Yucel Erbilgin, Salih Aksu, Ebru Koca, Cafer Adiguzel, Mahmut Bayik, Ibrahim Akalin, Zafer Gülbas, Meltem Akay, Ali Unal, Leylagul Kaynar, Ercument Ovali, Mustafa Yilmaz, Mustafa Yenerel, Simten Dagdas, Gulsum Ozet, Cem Ar, Yildiz Aydin, Teoman Soysal, Barbaros Durgun, Osman Ozcebe, Ajlan Tukun, Osman Ilhan, Ugur Ozbek. Effects of Imatinib Mesylate on the Renin Angiotensin System (RAS) Activity During the Clinical Course of Chronic Myleoid Leukemia (CML). The Journal of International Medical Research, 2009; 37:1018-1028.

19. Evrim KB, Nihan EU, Altan O, Bilge O, Carita E, Mikko H, Nina M, Reijo L, Gulay H, Terho L. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. Atherosclerosis. 2009 Apr 5.

20. Onat A, Hergenç G, Agirbaşli M, Kaya Z, Can G, Unaltuna NE. Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking. Clin Chem Lab Med. 2009;47(2):208-15.

21. Oksala N, Levula M, Airla N, Pelto-Huikko M, Ortiz RM, Järvinen O, Salenius JP, Ozsait B, Komurcu-Bayrak E, Erginel-Unaltuna N, Huovila AP, Kytömäki L, Soini JT, Kähönen M, Karhunen PJ, Laaksonen R, Lehtimäki T.ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries-Tampere vascular study. Ann Med. 2009;41(4):279-90

22. Coşan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoğlu F, Saruhan-Direskeneli G, Ustek D, Gül A. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçets disease. Clin Rheumatol. 2009 Dec;28(12):1385-8.

23. Gurses C, Ekizoglu O, Orhan N, Ustek D, Arican N, Ahishali B, Elmas I, Kucuk M, Bilgic B, Kemikler G, Kalayci R, Karadeniz A, Kaya M. Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia. Brain Res. 2009 Jul 24;1281:71-83.

24. Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK, Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U, “Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia”, Genet Test Mol Biomarkers 2009, 13:599-602.

2007-2008 Publications

1. Chtcheglova L.A, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdofer P. Localization of the Ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging. European Journal of Physiology. Eur J Physiol 2008 456:247–254

2. Öztürk M., Üstek D., Akbas F, Kösem M., Abaci N., Alagöl F., Öztürk G., Kotan Ç. The presence of erythropoietin receptor in parathyroid cells. J Endocrinol Invest. J Endocrinol Invest. 2007 Dec; 30(11): RC35-7

3. Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS. Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008 Nov-Dec;17(6):392-8.

4. Ustuner Z, Saip P, Yasasever V, Vural B, Yazar A, Bal C, Ozturk B, Ozbek U, Topuz E. Prognostic and predictive value of vascular endothelial growth factor and its soluble receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients. Med Oncol. 2008 ;25(4):394-9.

5. Chtcheglova LA, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdorfer P. Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging. Pflugers Arch. 2008 Apr;456(1):247-54.

6. Ince AT, Hatırnaz O, Ovünc O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S, IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2008 Jun;53(6):1683-92.

7. Sayitoğlu M, Ar MC, Hatırnaz O, Ongören S, Ure U, Başlar Z, Sırma,S Aydın Y, Özbek U, Ferhanoğlu B. Minimal Residual Disease (MRD) Detection with Translocations and T-Cell Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic Leukaemia Patients: A Pilot Study. Turkish Journal of Hematology. 2008 25 (3): 124-132.

8. Ustek D, Sırma S, Cakiris A, Cosan F, Oku B, Ozbek U. Cloning of chimerical translocations as positive control for molecular genetic diagnosis of leukemia. Turkish Journal of Hematology. 2008 25 (1):20-23

9. Pinar Kadioglu, Gokhan Oral, Muge Sayitoglu, Nevin Erensoy, Berna Senel, Nurperi Gazioglu, Aydin Sav, Gursel Cetin, Ugur Ozbek. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary (2008) 11:29–35.

10. Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Palmen J, Guclu F, Can G, Erginel-Unaltuna N., Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults., Clin Chem Lab Med. 2008;46(6):778-84.

11. Jia P, Zhang C, Huang XP, Poda M, Akbas F, Lemanski SL, Erginel-Unaltuna N, Lemanski LF., A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum., J Biomed Sci. 2008 Nov;15(6):789-99. Epub 2008 Jun 19.

12. Ozsait B, Kömürcü Bayrak E, Poda M, Can G, Hergenç G, Onat A, Humphries SE, Erginel Unaltuna N., CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome., Anadolu Kardiyol Derg. 2008 Oct;8(5):324-30.

13. Okumus G, Kiyan E, Arseven O, Tabak L, Diz-Kucukkaya R, Unlucerci Y, Abaci N, Unaltuna NE, Issever H.Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism., Clin Appl Thromb Hemost. 2008 Apr;14(2):168-73.

14. Sen F, Demirturk M, Abaci N, Golcuk E, Oflaz H, Elitok A, Kutluturk F, Issever H, Unaltuna NE, Ozbey NC, Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopituitary GH-deficient adult patients.,Eur J Endocrinol. 2008 May;158(5):615-22.

15. Deymeer F, Serdaroglu P, Parman Y, Poda M, Natural history of SMA IIIb:Muscle strength decreases in a predictable sequence and magnitude. Neurology, 2008;71:644–649

16. Ustek D, Ekmekçi C, Oku B, Cosan F, Cakiris A, Abaci N, Çelik S, Kamalı S, Hatemi G, Kasapçopur O, Özdogan H, Gül A. The MEFV Gene 3’-UTR Alu Repeat Polymorphisms in Patients with Familial Mediterranean Fever. Clin Exp Rheumatol. 2008, Jul-Aug;26(4 Suppl 50): S72-76

17. Sen F, Demirturk M, Abaci N, Golcuk E, Oflaz H, Elitok A, Kutluturk F, Issever H, Erginel-Unaltuna N and Ozbey N. Endothelial Nitric Oxide Synthase Intron 4a/b Polymorphism and Early Atherosclerotic Changes in Hypopituitary Growth Hormone Deficient Adult Patients European Journal of Endocrinology, 2008 May;158(5):615-22.

18. Kaya M, Gurses C, Kalayci R, Ekizoglu O, Ahishali B, Orhan N, Oku B, Arican N, Ustek D, Bilgic B, Elmas I, Kucuk M, Kemikler G. Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. Brain Res. 2008 May 7;1208:181-91.

19. Ustek D, Ekmekci CG, Selçukbiricik F, Cakiris A, Oku B, Vural B, Yanar H, Taviloglu K, Ozbek U, Gül A. Association between reduced levels of MEFV messenger RNA in peripheral blood leukocytes and acute inflammation. Arthritis Rheum. 2007 56(1): 345-50.

20. Thomas NS, Wiseman K, Spurlock G, MacDonald M, Ustek D, Upadhyaya M. A large patient study confirming that facioscapulohumeral muscular dystrophy disease expression is almost exclusively associated with an FSHD locus located on a 4qA-defined 4qter subtelomere. J Med Genet. 2007 44(3): 215-8.

21. Okumus G., Kiyan E., Arseven O., Tabak L., Bayrak EK., Unaltuna NE., Issever H. Platelet Glycoprotein Ia 807C/T And 873G/A Polymorphisms in Patients with Venous Thromboembolism. Clin Appl Thromb Hemost. 2007 13(1):101-3.

22. Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Acharya J, Hergenc G, Coban N, Can G, Erginel-Unaltuna N. The S447X Variant of Lipoprotein Lipase Gene is Associated with Metabolic Syndrome and Lipid Levels Among Turks. Clin Chim Acta. 2007 383(1-2):110-5.

23. Kadioglu P., Oral G., Sayitoglu M., Erensoy N., Senel B:, Gazioglu N., Sav A., Cetin G., Ozbek U. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary. 2007 Aug 17;

24. Ince AT, Hatırnaz O, Ovünç O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S, IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2007 Nov 3;

25. Yönal O, Hatirnaz O, Akyüz F, Ozbek U, Demir K, Kaymakoglu S, Okten A, Mungan Z. HFE gene mutation, chronic liver disease, and iron overload In Turkey. Dig Dis Sci. 2007 Nov;52(11):3298-302.

26. Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, Ferhanoğlu B, Ozçelik T, Ozbek U. The SOCS-1 gene methylation in chronic myeloid leukemia patients. Am J Hematol. 2007 Aug;82(8):729-30.

27. Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66.

28. Nurperi Gazioglu, Nevin Erensoy, Pinar Kadioglu, Muge Aydin Sayitoglu, Ismail Hakki Ersoy, Ozden Hatirnaz, Bunyamin Kisacik, Buge Oz, Mehmet Sar, Ugur Ozbek, Nejat Ciplak, Penbe Cagatay, Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas, Med Sci Monit, 2007,13(10): CR457-463.

2005-2006 Publications

1. Bayrak F., Komurcu-Bayrak E., Mutlu B, Kahveci G., Basaran Y., Erginel-Unaltuna N. Ventricular Pre-Excitation and Cardiac Hypertrophy Mimicking Hypertrophic Cardiomyopathy in a Turkish Family with a Novel PRKAG2 Mutation. Eur J Heart Fail. 2006 8: 712-715.

2. Aydın M., Hatirnaz O., Erensoy N., Ozbek U. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1 and GSTM1 Genes in the Susceptibility to Acute Leukemias. Am J Hem. Mar., 2006,81(3):162-70.

3. Müge Aydın-Sayioğlu, Inci Yıldız, Ozden Hatırnaz, Ugur Özbek Common Cytochrome p4503A (CYP3A4 and CYP3A5) and Thiopurine S-Methyl Transferase (TPMT) Polymorphisms In Turkish Population; Turkish Journal of Medıcal Sciences, 2006: 36 ,11-15.

4. Vural B, Chen L-C, Saip P, Chen Y-T, Ustuner Z, Gonen M, Jager E, Simpson AJG, Old LJ, Ozbek U, Gure AO, Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish SCLC patients and their correlation with clinical parameters, Cancer, 2005,103: 2575-83.

5. Junfeng Wang, Gamze Kilic, Muge Aydin, Zoe Burke, Guillermo Oliver, Beatriz Sosa-Pineda “Prox1 activity controls pancreas morphogenesis and participates in the production of “secondary transition” pancreatic endocrine cells. Dev.Biol., 2005: 286(1):182-94. 2003-

2003-2004 Publications

1. Zhang C, Meng F, Huang XP, Zajdel R, Lemanski SL, Foster D, Erginel-Unaltuna N, Dube DK, Lemanski LF. Downregulation of N1 gene expression inhibits the initial heartbeating and heart development in axolotls. Tissue Cell. 2004 36(1):71-81.

2. Frei K, Lucas T, Ramsebner R, Schofer C, Baumgartner WD, Weipoltshammer K, Erginel-Unaltuna N, Wachtler FJ, Kirschhofer K. A novel connexin 26 mutation associated with autosomal recessive sensorineural deafness. Audiol Neurootol. 2004 9(1):47-50.

3. Tukel T, Shalata A, Present D, Rachmilewitz D, Mayer L, Grant D, Risch N, Desnick RJ. Crohn Disease: Frequency and Nature of CARD15 Mutations in Ashkenazi and Sephardi/Oriental Jewish Families. Am J Hum Genet. 2004 Am J Hum Genet.

4. Muge Aydin, Ozden Hatirnaz , Nevin Erensoy , Ugur Ozbek; CYP2D6 and CYP1A1 mutations in the Turkish Population. Cell Biochem Funct , 2004:22: 1-3.

5. Yildiz P, Oflaz H, Cine N, Erginel-Unaltuna N, Erzengin F, Yilmaz V. Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD. Respir Med. 2003 97(12):1282-8.

6. Yildiz A, Yazici H, Cine N, Kazancioglu R, Akkaya V, Sever MS, Ark E, Erginel-Unaltuna N. Angiotensin converting enzyme gene polymorphism and development of post-transplant erythrocytosis. J Nephrol. 2003 16(3):399-403.

7. Duymaz-Tozkir J, Gul A, Uyar FA, Ozbek U, Saruhan-Direskeneli G. Tumour necrosis factor-alpha gene promoter region -308 and -376 G–>A polymorphisms in Behcets disease. Clin Exp Rheumatol. 2003 Clin Exp Rheumatol.

8. Kalayoglu-Besisik S, Caliskan Y, Sargin D, Gurses N, Ozbek U. Methylenetetrahydrofolate reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell transplantation. Transplantation. 2003 76(12):1775-7.

9. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U. Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003 35(5):454-9.

10. Gutierrez MI, Siraj AK, Bhargava M, Ozbek U, Banavali S, Chaudhary MA, El Solh H, Bhatia K. Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. Leukemia. 2003 17(9):1845-50.

11. Boylu-Akyerli CB, Ozbek U, Aydin-Sayitoglu M, Sirma S, Ozcelik T.Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol. 2003 129(10):604-5.

12. Savli H, Karadenizli A, Kolayli F, Gundes S, Ozbek U, Vahaboglu H. Expression stability of six housekeeping genes: A proposal for resistance gene quantification studies of Pseudomonas aeruginosa by real-time quantitative RT-PCR.J. J Med Microbiol. 2003 52(Pt 5):403-8.

13. Ozbek U, Sirma S, Agaoglu L, Yuksel L, Anak S, Yildiz I, Devecioglu O, Timur C, Meral A, Gedikoglu G. Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey. J Pediatr Hematol Oncol. 2003 25(3):204-8.

14. Onay UV, Kavakli K, Kilinc Y, Gurgey A, Aktuglu G, Kemahli S, Ozbek U, Caglayan SH. Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations. Br J Haematol. 2003 120(4):656-9.

15. Erginel-Unaltuna N, Akbas F. Improved method for molecular diagnosis of myotonic dystrophy type 1 (DM1). J Clin Lab Anal. 2003 18(1):50-4.

16. Akbas F, Erginel-Unaltuna N. DNA testing for Huntington disease in the Turkish population. Eur Neurol. 2003 50(1):20-4.

2001-2002 Publications

1. Komurcu E. and Erginel-Unaltuna N. Frequency of Platelet Glycoprotein Ia 807C/T and 873G/A Polymorphisms in Turkey. Am. J. Hemat. 200269, 1: 83-84.

2. Yıldız A., Yazıcı H., Cıne N., Akkaya V., Kayacan S.M., Sever M.S., Erginel-Unaltuna N. The effect of angiotensin converting enzyme gene polymorphism on chronic allograft dysfunction in living donor renal recipients. Clin Transplant. 2002Jun; 16 (3): 173-9.

3. Cine N., Hatemi A. C., and Erginel-Unaltuna N. Association of a polymorphism of the ecNOS gene with Myocardial Infarction in a subgroup Turkish MI patients Clin Genet. 2002 Jan; 61 (1):66-70.

4. Algun E, Abaci N, Kosem M, Kotan C, Koseoglu B, Boztepe H, Sekeroglu R, Aslan H, Topal C, Ayakta H, Uygan I, Alagol F, Erginel-Unaltuna N, Aksoy H. Clinical characteristics and genetic screening of an extended family with MEN2A. J Endocrinol Invest. 2002Jul-Aug;25(7):603-8.

5. Aşcıoğlu F., Akyüz F., Çetinkaya, U., Yılmaz, S., Koluaçık, S., Vural, B., Özbek, U., Turkish population data on nine short tandem repeat loci: HumCSF1PO, HumTHO1, HumTPOX, HumFES/FPS, HumF13B, HumVWA, D3S1358, D7S820, D16S539, Forensic Science International 2002, 126:252-3.

6. Akbas F., Serdaroglu P., Deymeer F., Aysal F., and Erginel-Unaltuna N. Molecular and clinical study of two myotonic dystrophy patients with homozygosity J. Med. Genet. 200138 (11): E40

7. Erginel-Unaltuna N., Peoch,K., Komurcu E., Acuner T., Issever H., Laplanche JL.. Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease. European Journal of Human Genetics. 20019, 965-968.

8. Tüysüz B., Dursun A., Kutlu T., Sökucu S., Çine N., Suo lu Ö., Erkan T., Erginel-Unaltuna N., Tümay G. HLA-DQ alleles in patients with celiac disease in Turkey. Tissue Antigens 2001 Jun; 57(6):540-542.

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