Dept. of Molecular Medicine Curriculum

MOLECULAR MEDICINE DEPARTMENT

POST GRADUATE AND DOCTORATE COURSES

NECESSARY AND ELECTIVE COURSES

 

Post Graduate

Necessary Courses: MOT 17033,  MOT 17001, MOT 17002, MOT 17003, MOT 17004, MOT 17005, MOT 17006, MOT 17007, MOT 17008, MOT 17009, MOT 17010, , MOT 17021

Elective Courses: MOT 17011, MOT 17012, MOT 17013, MOT 17015, MOT 17016, MOT 17017, MOT 108, MOT 115

Doctorate*

Necessary Courses: MOT 19034, MOT 19018, MOT 19022, MOT 19027, MOT 19028, MOT 19035, MOT 19036, MOT 19037, MOT 19039, MOT 207, MOT 215

Elective Courses: MOT 19019 , MOT 19023, MOT 19038, MOT 19040, MOT 19043, MOT 19044, MOT 209, MOT 213, MOT 214

 

* It is not required to continue to the courses taken in the master in doctorate period.

 

POST GRADUATE COURSES AND DEFINITIOINS

 

MOT 100: Seminar Course

Duration: 1 semester

Weekly Course Hours: 1 theorotical

Credits: –

ECTS : 6

Elective/Necessary: Necessary

Content: students own interest in the scientific topic is discussed in the classes with other students and lecturers

Aim: Introducing students to access the latest information in specific topics and gaining student to have an ability to literature presenting

 

MOT 17001: Basic Concepts of Biochemistry A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: The structure and functions of organelles, the structure and functions of cell membrane, water metabolism, acid-base and buffer solutions, the structural characteristics of amino acids, defining the structure and functions, structural characteristics of enzymes, the regulation of enzyme activity, enzyme inhibition and understanding of enzyme kinetics, bioenergetics, the role of citric acid cycle in metabolism, oxidative phosphorylation and analysis of ATP synthesis.

Aim: Introducing to biochemical reactions and macromolecular structures playing role in the biochemical reactions in the cell and organism

 

MOT 17002: Basic Concepts of Biochemistry B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 pratical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: Structural characteristics and digestion of carbohydrates, glycolisis, glycogenesis, pentose phosphate pathway, analysis of fructose and galactose metabolism, control of the glycogenesis and blood sugar level, structural characteristics and digestion of lipids, lipoprotein metabolism, cholesterol metabolism, protein digestion and analysis urea cycle.

Aim: Understanding of cell constituents and the related metabolisms

 

MOT 17003:  Molecular and Cellular Mechanisms of Diseases A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 2

Elective/Necessary: Necessary

Content: Definition of the characteristics of body fluids, blood content and biochemistry, the structure of hemoglobin and hemoglobinopathies, the mechanism of action of hormones, , analysis of hormones in protein and amino acid structure and the related diseases, analysis of hormones in steroid structure, analysis of eicosanoids and related diseases, a general look to the cancer biochemistry, analysis of cholesterol metabolism and diseases

Aim: Çunderstanding of mechanisms underlying the basics of various metabolism diseases

 

MOT 17004: Molecular and Cellular Mechanisms of Diseases B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2
ECTS : 2

Elective/Necessary: Necessary

Content: Analysis of amino acid metabolism and related diseases, analysis of carbohydrate metabolism  and diseases, analysis of coagulation system and related diseases, analysis of nervous system metabolism and diseases, muscle system metabolism, analysis of the liver and ethanol metabolism.

Aim: Understanding of the metabolisms underlying the basics of verious metabolism diseases

 

MOT 17005: Instrumental Analysis B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: Molecular techniques in gene analysis, genetic markers, DNA and RNA analysis, Polymerase Chain Reaction (PCR), mutation detection techniques, blotting techniques (Western, Southern, Northern), DNA microarray, Real time PCR, denaturated gradient gel electrophoresis techniques, HPLC technique, immunohistochemical techniques, flow cytometry, comperative genomic hybridisation, allel specific oligonucleotide hybridisation, in-situ hybridisation, protein analysis, a general look to recombinant DNA technology, cell cultre

Aim: Knowing the research techniques used in the molecular medicine field and the use areas of these techniques.

 

MOT 17006: Introduction to General Pharmacology and Toxicology A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 2

Elective/Necessary: Necessary

Content: Fundamental concepts of pharmacology, cell and organism respond against chemical agents, cellular localization of receptors, drug-receptor interactions, drug transportation through biological membranes, drug affects and metabolism, cellular membrane transport systems. Basic information of toxicology. The major drug classes affecting on the autonomic and central nervous system, and the basic mechanisms of action of these drugs.

Aim: Understanding of the basic concepts found in pharmacology and toxicology as well as the basics of drug effect mechanisms.

 

MOT 17007: Introduction to General Pharmacology and Toxicology B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 2

Elective/Necessary: Necessary

Content: Signal transduction system, G proteins and their functions, membran receptors and their functions, the changes arising as e result of receptor activation, toxic compounds, various chemicals associated and not associated with cancer and their toxic effect mechanisms on human health, toxicology and toxicogenetics.

Aim: Understanding of basic concepts of pharmacology, basics of drug-action mechanisms as well as the fundamentals of system pharmacology.

 

MOT 17008: Instrumental Analysis A

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

ECTS : 3

Elective/Necessary: Necessary

Content: Introduction to instrumental analysis, general laboratory rules, basic concepts in analysis and detection systems, laboratory quality-control evaluation methods and clinical laboratory automation, general principles of research, buffer, pH and physiological solutions, electrochemical and chemical sensors, tissue homogenisation methods, centrifugation and separation of cellular fractions, colorimetric methods, photometric methods, spectrophotometric analysis methods, measurement  of enzymatic activity , protein purification and detection methods, electrophotometric techniques, immunologic analysis methods, NMR, mass spectrometry, atomic absorption, a general look to the molecular diagnosis systems, introduction to DNA and RNA analysis methods, PCR analysis technique and its use areas, a general look to different PCR techniques, electrophoretic DNA analysis techniques.

Aim: Knowing the research techniques used in the molecular medicine field and the use areas of these techniques.

 

MOT 17009: Molecular Medicine A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: Introduction to molecular medicine,  the organic and inorganic structure elements of the cell, the regulation and mechanisms of biological events, structure and functions of cell organelles, cell responses to the environmental signals, cell division and its regulation, chromosome structure and chromosomal diseases, genetic systems outside the chromosome, the basic of genomic integration, dominant and ressesive genes, autosomal and genosomal inherity, identification of genes, gene map, variations in the genom and their relationships with diseases, a general look to nanobiotechnology.

 

MOT 17010: Molecular Medicine B

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

ECTS : 4

Elective/Necessary: Necessary

Content: Human genom organisation, transcriptional control of gene expression, DNA damage and repair mechanisms, mRNA splicing mechanisms and related diseases, roles of the transgenic animals in medicine, molecular mechanisms of aging, stem cell; genetic modification and in vivo use of stem cells, human genetic diseases and their controls.

Aim: Understanding of molecular and biochemical mechanisms in different diseases and the clinical approach of these mechanisms

 

MOT 17011: Transport Systems

Duration: 1 semester

Weekly Course Hours: 1 theorotical

Credits: 1

ECTS : 2

Elective/Necessary: Elective

Content: Membrane structure and biochemical characteristics of its components, the passage mechanisms and theories of molecules through biological membranes, transport systems, the biophysical characteristics of compound passage through the membranes, other passage ways through the epithelium and biological membranes, the pathology of membrane system.

Aim: Hücresel Identification of cellular transport systems pathologies and biological characteristics

 

MOT 17012: Introduction to Signal Transduction Systems

Duration: 1 semester

Weekly Course Hours: 1 theorotical

Credits: 1

ECTS : 2

Elective/Necessary: Elective

Content: Structure and dynamics of receptors, receptor activation, transmembrane signal transduction and events developing afterwards, themes related to ligand-receptor interaction, signal transduction systems associated with cell proliferation.

Aim: Identification of cellular signal pathways

 

MOT 17013: Introduction Cancer Biology A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 4

Elective/Necessary: Elective

Content: Definition and history of cancer, malign and benign tumors, cell proliferation and differentiation, classification of tumors, mechanisms of carcinogenesis, physical carcinogenesis, chemical carcinogenesis, viral carcinogenesis, molecular structures controlling the cell cycle, transcription factors in oncogenesis, growth factors and signal transduction, chromosomal stability, chromosomal translocations.

Aim: Definition of cancer and mechanisms belonging to cancer etiopathogenesis

 

MOT 17015: Introduction to Molecular Genetics

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 1

Elective/Necessary: Elective

Content: Structure and characteristics of nucleic acids, the mass and the organisation of genetic material, nucleic acid metabolism replication metabolism, transcription mechanism, protein synthesis, biochemical basic of genotype-fenotype interaction, control of gene expression, characteristics of genetic code, DNA damages and repair mechanisms, recombinant DNA technology, gene-environment interaction, mutation.

Aim: Knowing of the basic concepts in molecular genetics

 

MOT 17016: Physiology and Molecular Mechanisms of Exercise

Duration: 1 semester

Weekly Course Hours: 2 theorotical

Credits: 2

ECTS : 3

Elective/Necessary: Elective

Content: Metabolic, cardiovascular, pulmonary adaptations to exercise in the body and the molecular basis of their effects on health and performance will be discussed during the course.1.Mechanism of muscle contraction, structural and metabolic characteristics of the muscle types, neuromuscular effects of aerobic and strength workouts.2. Aerobic and anaerobic energy production, metabolic adaptation to exercise, lactate threshold, respiratory exchange ratio, oxygen deficit and debt.3. Pulmonary ventilation, blood gas exchange in the lungs and tissue, O2 and CO2 transportation in the blood, control of respiration, lung volumes and capacities, respiratory adaptation to the conditions of exercise.4. Exercise and adaptations of the endocrine system5. The effects of Exercise to VO2max, cardiac output (CO), stroke volume, heart rate and blood pressure, cardiovascular parameters etc.

Aim: Having the knowledge of; the effects of exercise on the health of the body. the effects of exercise on performance. the metabolic effects of exercise. the cardiovascular effects of exercise.

 

MOT 17017: Accessing Information and Evidence-Based Medicine

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: Having knowledge of ways of accessing information, learning of learning, following the developments in the new information in time, Evidence-Based Medicine.

Aim: Having the knowledge of how2 to access to the information in the field of health, evidence-based medicine, factors affecting the accuracy of the research, based on the quality assessment of research evidence, a systematic review and meta-analysis concepts.

 

MOT 17021: Introduction to Metabolism

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Necessary

Content: Amino-acid metabolism, carbonhydrate-energy metabolism, lipid metabolism, hormone metabolism and metabolic integration.

Aim: Knowing of the basic concepts of protein, lipid, carbonhydrate and hormone metabolism and the interaction between them.

 

MOT 115: Introduction Cancer Biology B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits:2

Elective/Necessary: Elective

Content:  Tumor markers, proliferation characteristics of tumors, antineoplastic agents and their mechanisms of action, cancer epidemiology, cancer chemoprevention, oncogenes and their functions, cell cycle, its control and regulative mechanisms, apoptosis and its regulation, GTP binding proteins, protein-protein interactions, cytoplasmic protein kinases and phosphatases, secondary messengers, nuclear receptor super family, tumor suppressor genes and effective mechanisms in the regulation of its functions, adhesion molecules and cell matrix, invasion and metastasis, angiogenesis in tumors and molecular mediators of angiogenesis.

Aim: Introducing to molecular mechanisms found in cancer formation, molecular analysis of biochemical changes seen in the organism during cancer.

 

DOCTORATE COURSES AND DEFINITIONS

 

MOT 200: Seminar Course

Duration: 1 semester

Weekly Course Hours: 1 theorotical

Credits: –

ECTS : 6

Elective/Necessary: Necessary

Content: students own interest in the scientific topic is discussed in the classes with other students and lecturers

Aim: Introducing students to access the latest information in specific topics and gaining student to have an ability to literature presenting

 

MOT 19018: General Biochemistry and Biochemical Reaction Mechanisms A

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

ECTS : 5

Elective/Necessary: Necessary

Content: Acid- base and buffer terms, structure and transport systems of biological membranes, structural characteristics of carbohydrates, structural characteristics of lipids, structural characteristics of amino acids, a general look to enzymes, bioenergetics, oxidative phosphorylation, hormone chemistry, analysis of mechanism of action of hormones.

Aims: Understanding of biochemical reactions and metabolic pathways formed in cell and organism

 

MOT 19019: Cancer Biology

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Elective

Content: Transformation mechanisms occuring in cancer, changes in tumor cells, carcinogenesis theories, cell cycle and its control, cell aging, death and control, changes in signal pathways in association with cell division and survival in cancer, genes associated with cancer, regulation mechanisms of genes associated with cancer, relationship between tumor and host, molecular mechanisms in individual malignities, epigenetic mechanisms in cancer, tumors wth epidermal origin and their characteristics,

epidermal kökenli tümörler ve özellikleri, mesenchymal tumors and their characteristics, hematologic malignities and their characteristics

Aim: Identification and analysis of signal transduction mechanisms, cell cycle, apoptosis and factors associated with angiogenesis.

 

MOT 19022: General Biochemistry and Biochemical Reaction Mechanisms B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 5

Elective/Necessary: Necessary

Content: Amino acid synthesis, amino acid degradation, amino acid metabolism disorders, lipid synthesis, lipid degradation, lipid metabolism disorders, carbohydrate synthesis, carbohydrate degradation, carbohydrate metabolism disorders.

Aim: Understanding of situations caused by the differences and deficiencies arising in the biochemical pathways in cell and organism

 

MOT 19023: Hormones and Metabolic Control A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 3

Elective/Necessary: Elective

Content: A general look to hormones, hormones with their structures, hormone chemistry, mechanisms of action of hormones, functions of hormones, hormones effective on amino acid metabolism, hormones effective on lipid metabolism and a general look to hormonal disorders.

Aim: Understanding of endocrine system and the elements of this system

 

MOT 19027: Molecular and Cellular Basics of Diseases A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2  practical

Credits: 2

ECTS : 5

Elective/Necessary: Necessary

Content: Cellular and extracellular matrix, cell injury, death, adaptation and repair, a molecular look to diseases, immune system, inflammation, bağışıklık sistemi, inflamasyon, shock and sepsis, hemostasis and trombosis.

Aim: Identification of molecular mechanism playing role in the etiopathogenesis of diseases

 

MOT 19028: Molecular and Cellular Basics of Diseases B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2  practical

Credits: 2

ECTS : 5

Elective/Necessary: Necessary

Content: Introduction to cancer and its molecular mechanisms, cell biology of cancer, cancer and signal transduction, cell death and signal transduction, angiogenesis mechanism, environment and cancer relationship, molecular mechanisms of atherosclerosis, molecular mechanisms of obesity.

Aim: Identification of molecular mechanisms playing role in the pathogenesis of diseases (obesity, cancer, atherosclerosis…) occuring frequently in the society

 

MOT 19035: Molecular Medicine B

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

ECTS : 5

Elective/Necessary: Necessary

Content: A general look to DNA sequence repeats and its effects on cellular functions, epigenetic factors in tumor formation, molecular look to cardiovascular diseases, oxidative stress, hypoxia and heart attack, hematology, pulmonology, gastroenterology, nephrology, dermatology, infectional diseases, viral diseases and molecular look to musculoskeletal system, a general look to nanobiotechnology.

Aim: Understanding and molecular definition of cellular functions which are damaged in various diseases.

 

MOT 19036: Clinical Laboratory Methods in Treatment A

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

ECTS : 5

Elective/Necessary: Elective

Content: Laboratory equipments, solutions and their preparation, laboratory security, automation in laboratory, liver function tests, tumor markers, renal function tests, electrolytes, acid-base physiology, quality control in laboratory.

Aim: Identification of the necessary background, laboratory conditions and experimental researchs for applying the clinical tests.

 

MOT 19037: Clinical Laboratory Methods in Treatment B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 5

Elective/Necessary: Elective

Content: Plasma proteins and their determination methods, urinary analysis, stool analysis, transuda and eksuda, hormone determination methods, hematological analysis, minerals and their determination methods, cerebrospinal fluid analysis.

Aim: Identification of methods used in the clinical diagnosis and surveillance of diseases

 

MOT 19038: Hormones and Metabolic Control B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 5

Elective/Necessary: Elective

Content: Etiology of diabetes mellitus, hormones effective in calcium metabolism, hormones effective in etiology of obesity, kidneys and hormones which they synthesise.

Aim: Understanding of the system biology and endocrine system, definition of hormonal changes occuring after the molecular mechanism disorders

 

MOT 19039: Molecular Pharmacology  B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

ECTS : 5

Elective/Necessary: Necessary

İçerik: Otocoids-Prostoglandins-NSAI mechanisms of action, pharmacology of central nervous system, cardiovascular pharmacology, pharmacology of endocrine system

Aim: Organ Identification of pharmacologic approachs peculiar to organ systems and gene therapies peculiar to individuals

 

MOT 19040: Cell Culture B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2  practical

Credits: 2

ECTS : 5

Elective/Necessary: Elective

Content: Preservation and conservation of the cells, freezing techniques: cryopreservation, haemocytometer; cell count and viability tests, contamination and cytotoxicity, kinetics of cell deaths in culturing systems, cell-line and its use areas in medicine, monolayer cell cultures, passage techniques, other techniques  used in cell cultures.

Aim: Identification of cell freezing, preserving and culture passage techniques.

 

MOT 19043: Molecular Mechanisms of Blood Pressure and Hypertension

Duration: 1 semester

Weekly Course Hours: 2 theorotical

Credits: 2

ECTS : 3

Elective/Necessary: Elective

Content: Blood pressure and essential, nonesansiyel molecular mechanisms in the development of hypertension. Physical and chemical factors that may lead to the development of hypertension

Aim: Having knowledge of Regulation of blood pressure, the etiology of hypertension, the molecular basis and pathogenesis of hypertension

 

MOT 19044: Molecular Mechanisms of Intellectual Functions

Duration: 1 semester

Weekly Course Hours: 2 theorotical

Credits: 2

ECTS : 3

Elective/Necessary: Elective

Content: Areas of the brain involved in learning and memory. Conditioning. According to the characteristics and terms of memory systems, molecules and enzymes that play a role in learning and memory. The role of plasticity.Memory disorders

Aim: Having knowledge of molecular mechanisms of intellectual functions of the brain and knowledge of memory disorders.

 

MOT 207:  Molecular Pharmacology A

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2  practical

Credits: 2

Elective/Necessary: Necessary

Content: Xenobiotic and biotransformation, cancer chemotherapy, antibiotics and their mechanisms of action

Aim:  Identification of pharmacogenetic terms and molecular approachs in pharmacology

 

MOT 209: Cell Culture A

Duration: 1 semester

Weekly Course Hours: 1 theorotical,2 practical

Credits: 2

Elective/Necessary: Elective

Content: Basic cell culture and laboratory order, equipments used in cell culture and their preparation, sterilisation techniques, cell culture environment, prophylactic use of antibiotics in cell and tissues, methods used in the cell selection, cell counting and identification tests, primary and secondary cell culture, culture of cells in different types

Aim: Presentation of cell culture laboratory and equipments and identification of sterilisation techniques

 

MOT 213: Molecular Genetics and Its Clinical Applications A

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

Elective/Necessary: Elective

Content: Genetiğin gelişimi, kalıtsal hastalıklarda moleküler ilkeler, rekombinant DNA uygulamaları, hemoglobin ve hemoglobinopatiler, biyokimyasal genetik.

Aim: Moleküler genetikte kullanılan yöntemler hakkında temel bilgilerin kavratılması

 

MOT 214: Molecular Genetics and Its Clinical Applications B

Duration: 1 semester

Weekly Course Hours: 1 theorotical, 2 practical

Credits: 2

Elective/Necessary: Elective

Content: Immunogenetics, chromosomes and chromosomal abnormalities, familial inheritance, genetic factors seen in some common diseases, single gene and chromosomal diseases, pharmacogenetics, population genetics and natural selection, applications in genetic engineering

Aim: Definition of molecular genetic techniques used in diagnosis of various diseases and its applications.

 

MOT 215: Molecular Medicine A

Duration: 1 semester

Weekly Course Hours: 2 theorotical, 2 practical

Credits: 3

Elective/Necessary: Necessary

Content: A general look to nucleic acids, nucleic acid metabolism, bioorganic chemistry, o molecular look to cell-cell and cell-matrix interactions, disease-environment-gene interaction, genetic basis of congenital malformations, molecular basis of multifactorial diseases, molecular approachs in aimed treatment.

Aim: Identification of cell building blocks and biochemical and molecular mechanisms taking place in cell-environment interaction

 

 

 

İstanbul University © 2017 All Rights Reserved