Genetics

The Department of Genetics was established in 1992. The main activities of the Department are conducting research and graduate education programs in molecular genetics and performing diagnostic service support. The main research topics are focused on genetic aetiology, epidemiology and association of leukemic, congenital and acquired heart diseases, common neurological disorders.

The facilities of the department are pre- and post- PCR labs, bacterial and eukaryotic cell culture labs complemented with a whole genome sequencing unit. The main departmental strategy is to use systems biology approach in solving complex biological problems. Different starting materials (DNA, RNA, miRNA) are procured during the experiments by the three workgroups. Other than the research and educational activities one very important activity is to provide molecular diagnostic support to clinics allocated in the university. Most of the tests used are standardized according to the international quality networks.

Activities in the department may be summarized under these topics:

  •   Coordination of the Medical Genetics Program of the Istanbul University,
  • Running national and internationally funded research projects,
  • Running projects funded by the university research fund,
  • Providing molecular genetics diagnostics.

Courses

1-) Molecular Hematology Course , 4-5 May, 2012

2-) Molecular Hematology Course, 23-24 December, 2011

3-) Molecular Hematology Course for Clinicians, 17-18 December, 2010

4-) Molecular Hematology Course for Clinicians, 19-20 February, 2010

5-) Molecular Genetics Course, Basic Genetics, 26-30 April, 2010

6-) 3nd Course in Integration of Cytogenetics, Microarrays and Massive Sequencing in Biomedical and Clinical Research Hibrid Course, 2010

Curriculum

OBLIGATORY AND ELECTIVE COURSES

MSc Courses:

SEMINAR course code  Old: GEN100 New: GNTK7001

BASIC MEDICAL GENETICS course code Old: GEN101  New: GNTK7002

Introduction to Human Genetics
Testing strategies and methods for genetic disorders
Mendelian Inheritance (autosomal dominant, autosomal recessive, X-linked recessive and X-linked dominant inheritance patterns)
Factors responsible from variable expresivity and penetrance
Non-clasic ınheritance; mitochondrial inheritance, mozaism, uniparental disomy and genomic impinting,
Multifactorial inheritance and its basic principles
Molecular and biochemical aspects of genetic disorders
Treatment modalities in genetics
Genetics of immune system
Cancer Genetics
Developmental Genetics and its main concepts

INTRODUCTION TO MOLECULAR GENETICS course code  Old: GEN111  New: GNTK7003

Structure of nucleic acids, replication, transcription, protein biosynthesis, control of gene expression, recombinant DNA technology, methods of making recombinant DNA molecules, isolation of cloning genes, selection of recombinants clones, identification of cloning genes, expression of cloning genes, gene function analysis, recombinant DNA in medicine and industry, model of immune system, oncogenes, anti-oncogenes, molecular analysis of cell cycle, isolation and mapping of disease genes, genome project and model organisms, human genome Project

INTRODUCTION TO CYTOGENETICS course code Old: GEN113 New: GNTK7004

MOLECULAR GENETICS course code Old: GEN112  New: GNTK7005

DNA structure, chromosome structure, gene structure, mutations, messenger RNA, protein synthesis, genetic code, DNA replication, recombination and repairing, transcription, RNA splicing, recombinant DNA technology, gene cloning, bioinformatics

GENETIC COUNSELING course code  Old: GEN114  New: GNTK7006

The importance of genetic counselling and its Basic concepts
Genetic counselling in single gene disorders
Genetic counselling in non-classic, non-mendelian and multifactorial diseases
Genetic counselling in chromosomal disorders
Genetic counselling for consanguinity
Genetic counselling in neurodevelopmental disorders
Genetic counselling for congenital malformation syndromes

PhD Courses:

BASIC GENETIC TECHNIQUES course code Old: GEN208 New: GNTK9007

Students undertake lab rotations and they are responsible for theoretical and practical knowledge of the lab work; DNA isolation, gel electrophoresis, imaging, karyotyping, clinical consultation

ADVANCED CYTOGENETIC TECHNIQUES course code  Old: GEN213 New: GNTK9008

SEMINAR course code  Old: GEN200  New: GNTK9013

CHROMOSOMAL DISEASES course code  Old: GEN210  New: GNTK9009

MENDEL AND NON-MENDEL DISEASES course code  Old: GEN211  New: GNTK9010

Clinical characteristics and genetic pathogenesis of Mendelian and non-Mendelian disorders

ADVANCED MOLECULAR GENETICS course code  Old: GEN212  New: GNTK9011

DNA, Gene structure (*DNA sequencing and genotyping: Standart techniques, automatic DNA sequencing, microarray based DNA sequencing, sequencing with using RFLP (restriction length polymorphysim) and STR (simple tandem repeats); *Gene identifying by cloning: Exon trapping, cDNA, RACE-PCR, mapping of transcription sites and determination of exon-intron borders; *Working with gene expression:
Homology research data banks, obtain antibody Human Genome Organization, an overview of the human genome organization (*An overview of human genome organization: copy number variations, the limited autonomy of the mitochondrial genome, DNA methylation and CpG islands; *organization, distribution and functions of human RNA genes: rRNA, tRNA, snRNA, snoRNA, miRNA, non-coding RNA…; human genome organization for polypeptide coding genes, non coding tandem repeats (Satellite, minisatellite, microsatellite), interspersed non coding repeats (LINE1, SINEs, pseudogenes, retrogenes, alu repeats)
Gene expression in human
(* An overview of gene expression: segmental restriction of gene expression; alternative transcription and translation; differential gene expression; epigenetic mechanisms, such as DNA methylation; imprinting and long range regulation of gene expression: differences between maternal and parental genome (non-equivalance), X-chromosome inactivation; *Ig and TCR gene organization and expression.
Genetic Mapping of Mendelian characters.
(* Recombinant and non recombinant; genetic markers ( development of the human genetic markers, informative and non informative meiosis; two-point mapping: Lod score calculation; *advantages of multipoint mapping: calculating Bayesian threshold; deep mapping, extended family tree and parental haplotypes
Mapping of human disease genes.
(* Principles and strategies in identifying disease genes: Positional cloning, using chromosomal abnormalities, finding candidate genes (using CGH for identification of submicroscopic chromosomal imbalance) Eight different examples on identification of disease genes (Sotos, Treacher Collins, Bronchio-Oto-Renal Syndrome, rhodopsin and fibrillin, Waardenbur Syndrome, Fanconi anemia, Sağırlıkta myosin 15 with deafness, DFNB3, otoferlin )

CURRENT TOPICS IN GENETICS course code  Old: GEN219  New: GNTK9012

topical subjects in medical genetics

Application

For more information, please visit the website of the Instite of Health Sciences

Regulations


Laboratories

FUNCTIONAL ANALYSIS OF NOVEL HEART SPECIFIC GENES

 -Functional Analysis Of Novel Heart Specific Genes in mice and man: A subtractive hybridization cDNA library specific to BALB/c mouse heart tissue was previously constructed in our laboratory. The purpose of this preliminary study was to find novel and rarely expressed genes that have important roles in cardiac formation and function.

The aim of the studies is to analyze the unknown transcripts in detail. Therefore, detailed bioinformatics analyses, Northern Blotting, and in situ hybridization techniques are exerted. As the final step, functional analysis based on cell culture systems is being planned. Moreover, the cell culture experiments will be designed considering the nature of the studied gene products.

-Deciphering ROR-a target genes in monocyte and endothelial cells and understanding their roles in atherosclerosis: Atherosclerosis is caused by inflammatory response initiated by endothelial cells and macrophages in the intima. ROR-alpha is a hypoxia-sensitive transcription factor which regulates systemic inflammatory response and cholesterol metabolism by its target genes expressed in the liver.

The aim of this project is to retrieve new data on the role of ROR-alpha atherosclerosis development. The project is expected to provide potential molecular targets that may be used for the prevention or the treatment of atherosclerosis in the future. Expressions of which are supposed to be changed depending on intracellular cholesterol level and circadian rhythm, will be tested in cell culture unit of the Immunology Department to elucidate relationship of atherosclerosis with the conditions in question. In the end of this project, novel genes involving atherosclerosis development and alterations of their expression profiles upon certain inducers will be indentified.  

 Molecular Cardivascular Epidemiology

 -Cardiovascular Clinical Epidemiology: Coronary Heart Disease is one of the major health problems causing death. As a study that reflects the profile for cardiovascular risk factors in the Turkish population, TEKHARF (TARF) Project has been running since 1990. In this long-term project, broad spectrums of conventional cardiovascular and metabolic risk factors are being investigated. The study has examined the hypothesis that functional variants of certain genes that are associated with cardiovascular events, and has identified that genes that play role in lipid, energy and glucose metabolism are important in risk determination.

Genetic Risk Factors for Cardiovascular Disease and Metabolic Syndrome in Turkish People followed for 15 years (TEKHARF-Genetics), TUBITAK 2005-2008: Our aim is to study the polymorphisms and haplotypes of the selected genes, and their association with cardiovascular and metabolic events. Thus, genetic risk factors that are of equal value to conventional risk factors will be identified. These genes that are found to be associated will be statistically analysed and identified as genetic risk factors for the Turkish population. Among these risk factors lipocalin family is one of the most important interest areas.

Association of the APOD gene with cardiovascular diseases and metabolic syndrome: ApoD belongs to lipocalin family, which plays role in the transport of hydrophobic molecules. Our previous findings show that ApoD is present among genes that are expressed mainly in the heart and its expression is significantly decreased on atherosclerotic plaques.

Genotype distribution of selected polymorphic points (“SNP”) are being identified in the TEKHARF-DNA bank of 2235 people specific for Turkish Population in association with cardiovascular diseases and/or metabolic syndrome. In addition to this, ApoD-protein analyses in peripheral blood of patients are planned for determination of the correlation between the discovered ApoD variances and protein amounts. Integration of study findings will contribute to the construction of the highly predictive “genetic risk panel” specific for the Turkish population.

Neuro-genetics

-Parkinson and Alzheimer Diseases Research:

Our study group works on the genetic basis of neurological disorders and holds about 1.085 DNA samples from patients with various movement disorders concerning  Parkinson’s Disease, Alzheimer Disease, dystonia, ataxia, Restless Leg Syndrome and healthy controls in the laboratory. This research is performed using a variety of methodologies. The goal of our research is to identify genetic variability that causes or contributes to neurological diseases in order to facilitate understanding of the molecular processes underlying disease. With this perspective, the ongoing projects are detailed as below:

Autosomal-recessive gene mutation frequencies in Turkish population: The objective is to evaluate the phenotype and frequencies of mutations in genes associated to Parkinson’s (PD) and Alzheimer’s Diseases.

PRKN Gene: The project team has finalized experiments on PRKN, DJ1 and Pink1 genes so far by MLPA (Multiplex Ligation-dependent Probe Amplification). Our data suggest that the PRKN gene mutations belong to the most frequent form associated with PD in Turkey. The prevalence rate with regard to the age of onset in our population is comparable to those previously described.

LRRK2 Gene: A total of 255 patients with parkinson from 223 families originating from Turkey were recruited to the study. Our results suggest that mutations in these regions of LRRK2 gene are not the main causes of PD in the Turkish population. In future, the rest of the genomic regions of the LRRK2 gene are going to be analysed in further detail.

DJ-1 and Pink1 Genes: Our study including exclusion of mutations in genes already known to be involved autosomal-recessive (AR) PD (Parkin, DJ-1 and Pink1), identification of new loci for AR parkinsonism by homozygosity mapping using SNP microarrays (in collaboration with the team from INSERM UMR/S 679, Prof Alexis Brice, Paris, France).

PSEN1, PSEN2 and APP Genes: The main goal of this research is to identify mutations in three genes namely, presenilin 1 (PSEN1), presenilin 2 (PSEN2) and amyloid precursor protein (APP), which are associated with familial as well as sporadic forms of Alzheimer disease.






Molecular Hematology Group

Intracellular interactions and functional analysis of WNT target genes

WNT pathway plays role in normal and malign hematopoietic cells. WNT proteins regulate “self renewal capacity” of hematopoietic stem cells and T and B-lymphocytes. We determined a multistep deregulation in the T-cell and B-cell acute lymphoblastic leukemia patients. Our goal is to determine the functional organization of molecules in different lineage leukemia. To do this we are using different approaches including shRNA interference, proximity ligation assay, reporter assay etc. Our findings so far, indicate that abnormal WNT signaling exists in T-ALL.

Genomic analysis of Childhood Acute Lymphoblastic Leukemia

Childhood acute lymphoblastic leukemia (ALL) is the most common malignancy in children and mechanisms of leukemic transformation are not well defined. In this project, we aimed to use of high resolution, genome-wide approaches to identify genomic aberrations contributing to leukemogenesis.

 T-cell ALL (T-ALL), results from the malignant transformation of normal developing T cells in the thymus, the so-called thymocytes. Aberrant regulations of signaling pathways that control normal T-cell developmentin the thymus are importantfor T-ALL leukemogenesis, where as chromosomalaberrations leading to abnormal fusion proteins, as often found as causative factor in precursor B-ALL, are not commonly found inT-ALL. In our first study, we performed whole genome expression arrays where we defined a new subset of T-ALL with deregulated WNT signaling and a novel molecular marker is found regulated in this T-ALL subgroup. Novel oncogenic proteins and miRNA deregulations are still in validation process.

Relapsed childhood ALL carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. Hence, in the second study, we aimed to understand the genetic events that contribute to relapse and chemo resistance, and identify novel targets of therapy. Three high-throughput assays were used to identify genetic and epigenetic changes at relapse. Using matched diagnosis/relapse bone marrow samples from children with relapsed B- ALL and T-ALL we evaluated gene expression, copy number abnormalities (CNA), and DNA methylation. There were many genetic alterations that evolved from diagnosis to relapse. We identified a distinct signature of differentially expressed genes from diagnosis to relapse associated with early relapse, and DNA methylation analysis found increased promoter methylation at relapse.

Targeted amplicon deep sequencing in high-risk ALL patients.

We are currently conducting a targeted amplicon deep sequencing screening of candidate genes in high-risk acute leukemia. We are a member of ELN (European Leukemia Net) and a collaborator of IRON II study, which is an international project under this organization. IRON II “The Interlaboratory RObustness of Next-generation sequencing (IRON) study” conducted for the deep analysis of the candidate risk genes in hematological malignancies. Targeted amplicon deep sequencing is a valuable tool to determine the background complexity (clonal variety) of the individual patients.

This study has started with the aim of sequencing high priority genes in a large cohort by using GS FLX sequencing instruments. We are currently conducting a targeted amplicon deep sequencing screening of candidate genes in high-risk acute leukemia. Istanbul University, Institute of Experimental Medicine (DETAE)-Genetics Department is participating the project in ALL and CML sub-teams. As a part of IRON II Study, we are aim to analyze candidate genes to characterizing molecular markers for disease classification, patient subgroup identification or new markers for treatment in ALL and CML patients.

Epilepsy and Rare Neurological Disorders Research Group:

Our main research interest mainly focuses on identification of genetic factors contributing to epilepsy. Epilepsy is a chronic heterogeneous disease manifested by recurrent, unprovoked seizures at any age. This is the second most common condition after headache with a prevalence of 0.5-1%. Among all epilepsies, idiopathic generalized epilepsy (IGE) is of great interest since it accounts for almost 30 per cent of all epilepsies and it tends to be genetically determined. The clinical features are characterized by age-related occurrence of generalized seizures in the absence of any detectable brain lesions or metabolic abnormalities. Childhood and juvenile absence epilepsy, juvenile myoclonic epilepsy and epilepsies with generalized tonic-clonic seizures represent the most common IGE syndromes.

–          Molecular genetic dissection of the heritable risk of IGEs by genome-wide linkage and association studies and candidate gene sequence analyses

–          Genome-wide array-based methylation profiling of parent-offspring trios displaying vertical inheritance of the IGE trait, i.e. one of the parents is affected along with the child.

–          Differential expression analysis of apoptosis and inflammation related genes in Mesial Temporal Lobe Epilepsy using human brain tissue.

–          Whole genome expression analysis using rat models of febrile seizure in order to investigate latent period of epileptogenesis.

We are also interested in studying rare inherited disorders, which are quite frequent in Turkey, mostly due to an increased rate of consanguineous marriages and presence of families having multiple children traditionally. Identification of new genes from families with rare disorders will eventually serve as models for complex disorders. We are currently working with such families displaying rare neurological disorders including disorders of brain development that are associated with epilepsy and ataxia. We would like to extend this research to other rare disorders.

–          Gene mapping pipeline: consanguineous families with rare recessive disorders with more than two affected individuals are recruited. In this regard, whole genome genotyping is performed in both affected and unaffected individuals from each family, followed by statistical analysis to map the gene region and to detect any pathogenic copy number changes in affected individuals. Candidate gene search is then employed for prioritized genes lying in this region in order to find disease-associated variants. If the gene region is extensive or if more than one gene region is detected, exome sequencing is used to study all exons in the genome. Genes in the linkage regions are primarily analyzed among the whole exome data. The variants identified are validated by conventional sequencing and scanning methods and then subjected to segregation analysis and frequency detection in a matched control group. In relatively small families where linkage analysis fails to map a single strong gene region, high-throughput screening is possible for all genes in candidate regions via exome sequencing.

Finally we have extended our research to SNP-array based ‘molecular karyotyping’ where we aim to detect copy number variations associated with children born with multiple congenital and mental retardation.

Immunogenetics

 Many disease states, including autoimmune diseases and cancer, are characterized by the presence of antibodies directed against self-antigens (autoantigens). These circulating antibodies or their antigen targets serve as potential biomarkers for understanding disease pathogenesis and defining its clinical outcomes, further with developing new therapeutic approaches.

Protein arrays are poised to become a central proteomics technology both important in basic research and biotechnological developments. Protein arrays are used in for in vitro functional interaction screens and particularly to detect antibodies or autoantigens in individual patient during disease or to monitor immune responses. Moreover, since most proteins are made by recombinant methods, there is direct connectivity between results on protein arrays and DNA sequence information.

We are mainly investigating new autoantigens in Behçet’s Disease (BD) which is a chronic inflammatory disorder of unknown pathogenesis, characterized by recurrent uveitis, skin lesions, oral aphthous and genital ulcers. Central nervous system involvement (Neuro-Behçet’s disease, NBD) is one of the most serious complications of BD and is encountered in 5-15% of the patients. Our approaches are based on protein array methods for the search of disease specific proteins that may have medical or diagnostic potentials as disease markers or drug targets and their corresponding gene sequences with respect to amino acid sequences of these antigens and their epitopes as well.

In our recent projects, we identified new autoantigens (PINK1, STIP1 and SWAP70) in BD or NBD by SEREX (Serological analysis of recombinant expression of cDNA expression libraries) and protein arrays (ImaGenes). New identified autoantigens are studied further for validation by ELISA and Western Blot.




Biohealth Computing Programme

Overview of the Program

Biohealth Computing Program (BHC) is a multidisciplinary Master of Science program that is organized by Istanbul University Institute of Experimental Medical Research Genetics Department. This program is the equivalence of the multidisciplinary Erasmus Mundus Master’s program offered at Université Joseph Fourier Grenoble (French), Universitat de Barcelona (Spain), Universita degli study di Torino (Italy), Universiteit Maastricht (Holland) and Universitatea de Ştiinţe Agricole şi Medicină Veterinară de Cluj-Napoca (Romania) universities.

Admission Requirements

Students who meet the conditions described in Istanbul University’s Graduate Education Legislation and who fulfill the following Erasmus Mundus acceptance conditions are eligible to apply to IU BHC program.

Direct acceptance: Students who have graduated from Medicine, Biology, Dentistry, Veterinary, Chemistry, Pharmaceutical, Molecular Biology and Genetics, Engineering (Computer, Electronics, Biomedical, Chemistry, Food, Environmental, Industrial) or Mathematics undergraduate programs will be directly accepted to the program. The students will be able to choose classes in accordance with their undergraduate degrees.

Acceptance of students holding undergraduate degrees other than the programs mentioned above will be decided by the Program’s Coordination Council.

The Objectives and Aims of the Diploma Program:

Objectives: The program aims to provide an interactive platform, where the students will be able to conduct research in close association with Public Universities, University Hospitals, Bioindustry Parks and Private Companies, in addition to exchange of information and to create and develop projects with peers and principal investigators from varying cultural and educational backgrounds. Thus, students graduating from this program will gain the skills to collaborate and create projects that may yield to industrial products, as well as to speed up the progress of translational research from bench to bedside.

Aims: In compliance with the aim of this program, the graduates will be equipped with the skills to compete in health technologies, pharmaceutical and biotechnological industries at an international level. Apart from job opportunities at universities, research centers; biotechnology, bioengineering and health sectors, and national and international companies as a Biohealth Computing Specialist, the graduates of this program can also continue for a PhD degree in Genetics, Biotechnology or Bioinformatics tracks.

For more information please visit: http://biohealthcomputing.istanbul.edu.tr/

PhD

Sinem   FIRTINA

Deniz    ÇAKMAK

Melda   SARIMAN

Zeliha    EMRENCE

Fatma Yeşim      KESİM

Emrah   YÜCESAN

Burcu    DURSUN

Zeynep Gamze GÜVEN

Burcu    AKIN

Emrin    GÜNER

Hüseyin               GEDİK

Özkan   ÖZDEMİR

Sevcan MERCAN

Nihan Hande     CEYLAN

Bircan   YILMAZ

Ekin       KUNTSAL

Gökhan               TANFER

Eren      VURGUN


MSc

Orçun   Taşar

Fulya     TOZAN

Eda        GÜNGÖRÜRLER

Khusan KHODAHAEV

N. Ece   BİBEROĞLU

Fatma   RENGİN COŞKUN

Nurol    CİMİNOĞLU

Filiz        ÇAVUŞ

Muhammed A. KALKAN

Fatma   SARI

Onur     ŞİMDİ

Sinem   İZDEŞ

Fatih U.                Karaoğlan

Ali Cem YEĞİN

Damla   ÇAKIR

Ebru      ÖZER

İrem Yağmur     DİKER

Sinem   ŞİŞKO

Burak    İŞLEK

Esra       KAYIKÇI

Nilgün   GENÇ

Tuğba   AYDINTUĞ

Burcu    TUNÇ

Gizem   ATAĞ

Hilal       HEKİMOĞLU

İldeniz  USLU

Elif          DARBUKA

Rabia Merve      CEYLAN

Cemil    ALTUNAY

İskender Sinan GENCO

Esra       BAYTAK

Edip       IŞIK

Burcu    SALMAN

Tuğba   Tanrıverdi

Fidan     BİROL

Garen   HARYANYAN

Genetic Diagnosis

Neuromuscular Disorders

 

-Duchenne Muscular Dystrophy Gene Deletions

-Duchenne Muscular Dystrophy MLPA Analysis

-Becker Muscular Dystrophy Gene Deletions

-Spinal Muscular Atrophy Gene Deletions

-Huntington Disease Genetic Analyses (trinucleotide repeat expansion analysis)

 

Hematological Malignancies

 -ALL t(9;22) BCR- Abl p190,

-ALL t(9;22) BCR- Abl p210,

-ALL t(4;11)

-ALL t(12;21)

-ALL t(1;19)

-AML t(15;17)

-AML t(8;21)

-AML İnv(16)

-KML t(9;22) Quantitative -ABL Tyrosine Kinase Gene Mutations

-FLT3-ITD and D385 Gene Mutations

 

Coagulation Diagnosis

-Factor V (Leiden) Mutation

-Prothrombin G2021OA polymorphism

Projects 

Supported by the Istanbul University Scientific Research Project Unit 

Cardiovascular

 -Aterosklerotik plaklarda aday miRNA’lar ile hedef genlerin ekspresyon düzeylerinin belirlenmesi (2013-2015) (İ.Ü. BAP Normal-28473), yürütücü: Dr. Evrim bayrak Kömürcü

– Kardiyovasküler hastalıklar için aday gen polimorfizmlerinin TaqMan probları ile optimizasyon çalışması (BYP), (2011-2012) (İ.Ü. BAP Proje no:19545)

Yürütücü:Dr. Evrim bayrak Kömürcü

 – Aterosklerozda Rol Alan Yeni Aday Genlerin Belirlenmesi (2009-2012) (İ.Ü. BAP Proje No: 19384)  Yürütücü: Prof.Dr. Nihan Ünaltuna

 –  ‘Subtractive’ Hibridizasyon kütüphanesinden seçilen yeni genlerin analizi  (2008-2010) (İ.Ü. Araştırma Fonu  ACİP: Proje no:3107) Yürütücü: Prof. Dr. Nihan Erginel-Ünaltuna

-Kardiyovasküler Hastalıklar için Doku ve DNA/RNA Bankalaması  (2009-2012) (İ.Ü. Araştırma Fonu (YÖP) : 3186)  Yürütücü : Prof. Dr. Nihan Erginel-Ünaltuna

-Monosit ve Endotel Hücrelerinde ROR-Alfa Hedef Genlerinin Tanımlanması ve Ateroskleroz İçin Önemi  (2010-2013) (İ.Ü. Araştırma Fonu : 3680) Yürütücü : Prof. Dr. Nihan Erginel-Ünaltuna

-TEKHARF Çalışmasında APOA1 -75G/A Polimorfizminin Önemi  (2010-2011) (İ.Ü. Araştırma Fonu : 4578)  Yürütücü : Evrim Bayrak-Kömürcü

–  Irx4 Geninin Hipertrofik Kardiyomiyopati ile İlişkisi   (20.08.2003 / 20.08.2004) (İ.Ü. Araştırma Fonu 136/20082003) Yürütücü : Prof. Dr. Nihan Erginel-Ünaltuna

–  Resistin geninin metabolik sendrom ve kalp hastalıklarındaki önemi (05.05.2006 / 02. 2008) (İ.Ü. Araştırma Fonu 50/05052006 ) Yürütücü : Prof. Dr. Nihan Erginel-Ünaltuna

 

Neurogenetics

–  Türk Parkinson Hastalarında LRRK2 Geni Analizi  (2008-2012) (İ.Ü. Araştırma Fonu : 513) Yürütücü : Doç. Dr. Haşmet Ayhan Hanağası  (Nöroloji AD)

 

-‘Türk Popülasyonunda PSEN1 (Presenilin 1), PSEN2 (Presenilin 2) ve APP (Amiloid Prekürsör Protein) Gen Mutasyonlarının Alzheimer Hastalarında Araştırılması  (2008-2012)(İ.Ü. Araştırma Fonu : 3031)  Yürütücü : Doç. Dr. İbrahim Hakan Gürvit  (NörolojiAD)

Cancer

–  Tüm Genom Ekspresyon ve Genotipleme Sistemi (2011-2014) (İ.Ü. BAP: 11021)

Yürütücü: Prof. Dr. Uğur Özbek

 

-Lösemi hücre serilerinde B-katenin-SiRNA uygulaması sonrası WNT sinyal ileti yolunun protein analizi ile incelenmesi  (2008-2010)  (İ.Ü. Araştırma Fonu : 1667)Yürütücü : Dr. Müge Sayitoğlu

 

 

-Wnt sinyal ileti yolunda görevli Wnt5A, Lef-1 ve Tcf-1 genlerinin akut lenfoblastik lösemi (ALL) hastalarındaki ekspresyonu ve metilasyonlarının araştırılması  (2005-2007) (İ.Ü. Araştırma Fonu : 355/03062005) Yürütücü : Dr. Müge Sayitoğlu

 

 

-Anti-SOX, anti-ZIC, anti-Hu, anti-CRMP, anti-recoverin, anti-amphiphysin I ve diğer antijenlerin küçük hücreli akciğer kanseri (KHAK) ve riskli gruplarda taranması(2006-2008) (İ.Ü. Araştırma Fonu : 491/05052006)  Yürütücü : Doç. Dr. Burçak Vural

 

 

-Küçük Hücreli Akciğer Kanseri (KHAK) hastalarında ve riskli kontrollerde, bazı metabolik enzim polimorfizmlerinin sıklıkları ve bu polimorfizmlerin klinik parametrelerle ilişkileri

(2006-2008)  (İ.Ü. Araştırma Fonu : 483/05052006 )  Yürütücü : Prof. Dr. Uğur Özbek

 

 

-Temporal Lob Epileptogeneziyle  İlişkili Genlerin Ekspresyon Analizi (2006-2009) (İ.Ü. Araştırma Fonu : T-794/07032000)  Yürütücü : Doç. Dr. Nerses Bebek

 

 

-B-Hücre Alt guruplarının Akım Sitometri Yöntemi ile Ayrıştırılması  (2009) (İ.Ü. Araştırma Fonu : 3817)  Yürütücü : Dr. Müge Sayitoğlu

 

– Wnt hedef genlerinin hücre içi interaksiyonları ve fonksiyonel analizi (2010-devam ediyor) (İÜ BAP: 5785) Yürütücü: Doç.Dr. Müge Sayitoğlu

 

Immunogenetics

-Pirin ve Hücre İskeleti Proteinleri Arasındaki İlişkinin İncelenmesi (2008-Devam) (BAP proje no:1235) Proje Yürütücüsü: Doç. Dr. Duran Ütsek

 

-MEFV geni 3′-UTR bölgesinin mRNA regulasyonu üzerine  etkisinin Araştırılması (2008-Devam) (BAP proje no: 2669) Proje Yürütücüsü: Doç. Dr. Duran Ütsek

 

– Deneysel hipertiroidizmde pulmoner arteriyal basınç değişikliklerinde kardiyak ve endotelyal disfonksiyonun rolü (2009-2012) (İ.Ü. BAP: 3131) Proje Yürütücüsü: Prof. Dr.  Gönül ŞİMŞEK

– IGF-1 geni promoter bölge polimorfizmi ve tiroid kanseri arasındaki ilişkinin araştırılması(2010-2012) (İ.Ü. BAP:6922) Proje Yürütücüsü: Dr. Özlem Soyluk

 

–    Tiroidektomi sonrasında erken dönemde leptin ve adiponektin konsantrasyonları (2011-2012) (İ.Ü.BAP: 10466) Proje Yürütücüsü: Prof. Dr. Neşe Özbey

 

–   X’e bağlı agammaglobulinemi (XLA) fare modellerinde B-hücre hasarının düzeltilmesi (2011-2012) (İÜ BAP:11319) Yürütücü: Dr. Yuk Yin Ng

 

–  Manyetik Boncuklar Yardımı ile CD34+ hücrelerinin İzolasyonu (2011-2012) (İÜ BAP: 17063) Yürütücü: Prof. Dr. Uğur Özbek

Other Projects

–  İnfertil bireylerde spermatozoal RNA’ların embriyo gelişim potansiyeli ile ilişkisinin araştırılması.  (2012-2013) (İ.Ü. BAP: 13930) Proje Yürütücüsü: Dr. Bilge Özsait

–  Stratejik Yönetim Temel Kavramları ve SWOT Analizi (2010-2012) (İ.Ü. BAP) Yürütücü: Prof. Dr. Uğur Özbek

 

 Supported by the Scientific and Technological Research Council of Turkey

 

Cardiovascular

 

-Türk Erişkinlerinde Kalp Hastalığı ve Metabolik Sendrom Genetik Risk Faktörleri (TEKHARF- Genetik)  (01.10.2005 /  01.1.2008) (TÜBİTAK 105S058)   Yürütücü : Prof. Dr. Nihan Erginel-Ünaltuna

 

Cancer

-Akut Lösemilerde WNT Sinyal İleti yolunun araştırılması ve tedavide yarar sağlayacak hedef moleküllerin belirlenmesi (2006-2010) (Tübitak : SBAG106S112) Yürütücü : Dr. Müge Sayitoğlu

 

-Nöro-behçet Hastalarında Otoreaktivite Gelişen Antijenlerin Serex Metodu ile Belirlenmesi

(2008-…)  (Tübitak : 108S053)  Yürütücü : Doç. Dr. Burçak Vural

 

-Nöro-behçet Hastalarında Otoreaktivite Gelişen Antijenlerin Serex Metodu ile Belirlenmesi

(2008-…)  (Tübitak : 108S053)  Yürütücü : Doç. Dr. Burçak Vural

 

-Kronik Myeloid Lösemi, BCRABL füzyon geninin lentivektör aracılıklı shRNA interferans ile baskılanması (2005-2007) (SBAG-3145) Yürütücü: Doç. Dr. Duran Üstek

 

-Multipl myelomda kemik iliğindeki lokal renin-anjiyotensin sisteminin.etiopatogenezdeki rolü (2005-2007) (Tübitak : SBAG 105S432)  Yürütücü : Sevgi Kalayoğlu

 

-Nöro-behçet Hastalarında Otoreaktivite Gelişen Antijenlerin Serex Metodu ile Belirlenmesi

(2005-2008)  (Tübitak : 105S112)  Yürütücü : Prof. Dr. Uğur Özbek

 

– T Hücreli Akut Lenfoblastik Lösemi Hastalarının Genom Boyu Anlatım Analizi (2010-2013) ( TÜBİTAK: 109S395) Yürütücü: Prof. Dr. Uğur Özbek

 

Neurogenetics

– İdiyopatik Jeneralize Epilepsilerde Tüm Genom Metilom Analizi (2010-devam ediyor)

(TÜBİTAK: 109S218) Yürütücü: Prof. Dr. Uğur Özbek

 

Other Projects

–   Yard.Doc.Dr.Selcuk SOZER TOKDEMIR (2011-2014) (TUBITAK-1001: 111S173)

 

– Kefir tanelerindeki mikrobiyal kominitenin metagenomik analizi (2011-2013) (TÜBİTAK: 111T369) Proje Yürütücüsü: Yar. Doç.Dr. Handan Can Otu

Support from other Foundations

 

Supported by the Turkish Society of Hematology

-WNT sinyal ileti yolunda görevli Wnt10b ve B-katenin  genlerinin akut lenfoblastik lösemi (ALL) hastalarında ekspresyonu ve metilasyonunun araştırılması  (2005) (Türk Hematoloji Derneği : 2005) Yürütücü : Prof. Dr. Uğur Özbek

 

– B Hücreli Akut Lenfoblastik Lösemilerde PAX5 Geninin Araştırılması (2009-2010) Yürütücü: Sinem Özdemirli

 

Supported by State Planning Organization

-Lösemilerin Etiyolojisi, İlaç ve Gen Tedavisi İçin Moleküler Genetik Yaklaşım (2005-2008)

(DPT : 2005K120430)  Yürütücü : Prof. Dr. Uğur Özbek

 

Supported by National Institutes of Health (NIH)

-Whole Genome Association Study for Identification of Behcet’s Disease Susceptibility Genes (2007-Devam) Yürütücü: Prof. Dr. Ahmet Gül

 

Supported by Seventh Framework Programme, FP4

An integrated clinical and scientific approach for craniofacial malformations (2008-Devam) (E-Rare JTC FP7) Yürütücü: Dr. Bernd Wolnik

 

Thesis Projects

– Mikro RNA’ların Behçet Patogenezindeki Rolleri (2011-2013) (İ.Ü. BAP:15205) Yürütücü: Msc. Aydın Karabulut Danışman: Prof. Dr. Uğur Özbek, Prof.Dr. Günnur Deniz

 

– Behçet Hastalığı-genom analiz çalışmasında belirlenen IL23R-IL12RB2 bölgesindeki varyantın (rs924080),  IL23R ve IL12RB2 genlerinin ekspresyonları ile ilişkisininin araştırılması (2011-2012) (İ.Ü. BAP: 18969) Yürütücü: Tib. Bio. Filiz Çavuş Danışman: Doç.Dr. Burçak Vural

 

– Stem-loop RT-PCR yöntemi ile miRNA gen anlatımının tespiti (2010-devam ediyor) (İ.Ü.BAP: ) Yürütücü: Bio. Nurhan Mavi Danışman: Prof. Dr. Uğur Özbek, Doç.Dr. Müge Sayitoğlu

 

– T Hücreli Akut Lenfoblastik Lösemide Tüm Genom  Analizi (2011-2013) (İ.Ü.BAP: 13107) Yürütücü: Msc. Özden Hatırnaz Danışmanı: Prof. Dr. Uğur Özbek

 

– Kompleksin 1 ve Behçet Hastalığı Patogenezindeki Olası Rolünün Araştırılması (2011-2012) (İ.Ü.BAP: 18470) Yürütücü: Uzm. Bio. Aris Çakiris,  Danışmanı: Doç.Dr. Duran Üstek

–Ateroskleroz patogenezinde rol oynadığı düşünülen iki aday genin koroner arterlerdeki aterosklerotik plaklarda gen ifadesinin araştırılması (2011-2012) (İÜ BAP: 16998) Yürütücü: Bio. Cem Horozoğlu,  Danışmanı: Prof.Dr. Nihan Ünaltuna

 

– Östrojen reseptör alfa (ESR1) gen promotörünün metilasyon analizi (2011-2013) (İÜ BAP: 10495) Yürütücü: Uzm. Bio. Filiz Güçlü-Geyik, Danışmanı: Prof.Dr. Nihan Ünaltuna

 

– Ateroskleroz’da rol alabilecek yeni bir aday genin fonksiyonel analizi ve bu genin kardiovasküler hastalıklar ile ilişkisi (2010-2012) (İÜ BAP: 10979) Yürütücü: Uzm. Bio.Neslihan Çoban, Danışmanı: Prof.Dr. Nihan Ünaltuna

 

-Temporal Lob Patogenezinde Enflamasyon İle İlgili Genlerin Ekspresyonlarının Araştırılması (2008-…)  (İ.Ü. Araştırma Fonu : 3391)  Yürütücü : Özkan Özdemir Tez Danışmanı : Prof. Dr. Uğur Özbek

 

-B Hücreli Akut Lenfoblastik Lösemilerde PAX5 Geninin Araştırılması (2008-2010) (İ.Ü. Araştırma Fonu : 3349) Yürütücü : Sinem Özdemirli Tez Danışmanı : Prof. Dr. Uğur Özbek

 

-PINK1 ve SWAP70 Genlerinin Klonlanması ile Oluşturulan Proteinlerin Behçet Hastalarında ELISA Yöntemi ile Taranması (2008-2010) (İ.Ü. Araştırma Fonu : 3351) Yürütücü : Elif Uğurel  Tez Danışmanı : Prof. Dr. Uğur Özbek

 

– Bifosfonat ve Statinlerin Çok Yönlü Etkisinde ROR-Alfa Transkripsiyon Faktörünün Olası Rolü (2009-2012) (İ.Ü. Araştırma Fonu: 4097) Yürütücü: Çağrı Güleç, Tez Danışmanı:            Prof. Dr. Nihan Erginel-Ünaltuna

 

-Çıkartılmış (“subtractive”) hibridizasyon tekniği ile kalbe özgü bilinmeyen genlerin izolasyonu ve analizi (19.02.2001 / 19.10.2002) (İ.Ü. Araştırma Fonu 1062/19022001) Yürütücü : Evrim Kömürcü Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Subtractive hibridizasyon kütüphanesinden izole edilen ve kalp gelişiminde önemli rolü olduğu düşünülen genlerin analizi (19.02.2001 / 19.06.2003) (İ.Ü. Araştırma Fonu 1063/19022001) Yürütücü : Bilge Özsait Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-In situ hibridizasyonla vertebralı doku kesitlerinde mRNA ekspresyonunun gösterilmesi  (19.02.2001/10.07.2004) (İ.Ü. Araştırma Fonu  1061/19022001)Yürütücü : Mehveş Poda Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

–  Troponin T Gen Mutasyonlarının Türk Populasyonundaki Dilate Kardiyomiyopatili Hastalarda Taranması  (05.01.2004 / 03.07.2006) (İ.Ü. Araştırma Fonu  534/21102004)  Yürütücü :  Filiz Geyik Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Metabolik Sendromlu Hastalarda ABCA1 Genindeki Mutasyonların Saptanması (17.03.2004 / 03.07.2006)  (İ.Ü. Araştırma Fonu  608/17032005) Yürütücü: Neslihan Çoban Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Hipertrofik Kardiyomiyopatili Hastalarda HOP Gen Mutasyonlarının Analizi  (21.10.2004 / 10.07.2006) (İ.Ü. Araştırma Fonu 533/21102004) Yürütücü: Çağrı Güleç. Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

– Türk toplumundaki hipertrofik kardiyomiyopatili hastalarda kardiyak troponin I gen mutasyonlarının  taranması   (05.01.2004 / 05.07.2006) T53221102004 Yürütücü : Zehra Simin Ataç Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

–  BOB(CD8 Beta OPposite) geninin hipertrofik kardiyomiyopatili hastalarda mutasyon analizi   (05.01.2004 / 05.07.2006) T-531/21102004 Yürütücü : Neslihan Abacı Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Kalbe özgü subtractive hibridizasyon kütüphanesinden seçilen yeni genlerin analizi (06.2006 / 25.11.2008) İ.Ü. Araştırma Fonu Yürütücü : Evrim Kömürcü-Bayrak Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Western Blot yöntemi ile müsküler distrofi proteinlerinin tanımlanması (06.2008’de bitti.) İ.Ü. Araştırma Fonu Yürütücü : Eda Becer Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Otozomal resesif geçişli Parkinson hastalığında Parkin (PARK2) geni mutasyonlarının araştırılması Otozomal resesif geçişli Parkinson hastalığında Parkin (PARK2) geni mutasyonlarının araştırılması (06.2008’de bitti.) İ.Ü. Araştırma Fonu  T-56/15122006  Yürütücü : Burcu Dursun Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-T-ALL Hastalarında NOTCH1 Mutasyonunun Araştırılması  (2006-2008)  (İ.Ü. Araştırma Fonu : 819) Yürütücü : Yücel Erbilgin  Tez Danışmanı : Prof. Dr. Uğur Özbek

 

-Pediatrik AML hastalarında kromozomal değişiklikler ve FLT3 gen mutasyonlarının araştırılması  (2006-2008) (İ.Ü. Araştırma Fonu : 1850) Yürütücü : Ender Coşkunpınar  Tez Danışmanı : Prof. Dr. Uğur Özbek

 

-Apolipoprotein D gen varyasyonlarının kardiovasküler hastalıklar ve metabolik sendrom ile ilişkisi. (2009’da bitti.) İ.Ü. Araştırma Fonu   Proje Numarası:2137 Yürütücü : Emrin Güner Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Subtractive cDNA hibridizasyon kütüphanesinden seçilen taube nuss geninin fonksiyonel analizi (2009’da bitti). İ.Ü. Araştırma Fonu Yürütücü : Berna Yüzbaşıoğulları Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Alzheimer Hastalarında PDGF ve Ang-2 Genotiplerinin ve Plazma Konsantrasyonlarının Araştırılması (2009’da bitti.) İ.Ü. Araştırma Fonu   Proje Numarası : 2590 Yürütücü : Mukaddes Pala Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

 

-Subtractive hibridizasyon cDNA kütüphanesinden elde edilen kalbe özgü yeni genlerin genomik organizasyonlarının belirlenmesi ve fonksiyonel analizleri (2010’da bitti. İ.Ü. Araştırma Fonu Yürütücü : Bilge Özsait Tez Danışmanı : Prof. Dr. Nihan Erginel-Ünaltuna

International

​

2012 – 2013 Publications

  1. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St  George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer’s disease. N Engl J Med. 2013 Jan 10;368(2):117-27.
  2. Onat A, Can G, Ornek E, Ayhan E, Erginel-Ünaltuna N, Murat SN. High Serum Apolipoprotein E Determines Hypertriglyceridemic Dyslipidemias, Coronary Disease  and ApoA-I Dysfunctionality. Lipids. 2013 Jan;48(1):51-61.
  3. Guclu-Geyik F, Onat A, Coban N, Komurcu-Bayrak E, Sansoy V, Can G, Erginel-Unaltuna N. Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women. Mol Biol Rep. 2012 Dec;39(12):10907-14.
  4. Komurcu-Bayrak E, Ozsait B, Erginel-Unaltuna N. Isolation and analysis of genes mainly expressed in adult mouse heart using subtractive hybridization cDNA  library. Mol Biol Rep. 2012 Aug;39(8):8065-74.
  5.  Lohmann E, Guerreiro RJ, Erginel-Unaltuna N, Gurunlian N, Bilgic B, Gurvit H,  Hanagasi HA, Luu N, Emre M, Singleton A. Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients. Neurobiol Aging. 2012 Aug;33(8):1850.e17-27.
  6. Hannon M, Lohan F, Erbilgin Y, Sayitoglu M, O’Hagan K, Mills K, Ozbek U, Keeshan K. Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. Br J Haematol. 2012 Jul 6.
  7. Yavuz EN, Ozdemir O, Catal S, Bebek N, Ozbek U, Baykan B. Bromodomain-Containing Protein 2 gene in photosensitive epilepsy. Seizure. 2012 Jul 3.
  8. Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K. Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray Cross-Complementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange Frequency in Patients with Chronic Lymphocytic Leukemia. Genetic Testing and Molecular Biomarkers Volume: 16 Issue: 4 Pages: 287-291. APR 2012.
  9. Vural B, Yakar F, Derin D, Saip P, Yakar A, Demirkan A, Karabulut A, Ugurel E, Cine N, Kilicaslan Z, Tüzün E, Ozbek U. Evaluation of Glutathione S-Transferase P1 Polymorphisms (Ile105Val and Ala114Val) in Patients with Small Cell Lung Cancer. Genet Test Mol Biomarkers. 2012 Feb 17.

           10. EPICURE Consortium, Leu C, de Kovel CG, Zara F, Striano P, Pezzella M,       Robbiano A, Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuss-Lie AA, Hallman K, Kunz WS, Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A, Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U, Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies. Epilepsia. 2012 Feb;53(2):308-18.

11. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia.Leuk Res. 2012 Jan;36(1):87-92.

12. Gialluisi A, Pippucci T, Anikster Y, Ozbek U, Medlej-Hashim M, Mégarbané A, Romeo G.Estimating the allele frequency of autosomal recessive disorders through mutational records and consanguinity: the Homozygosity Index (HI).Ann Hum Genet. 2012 Mar;76(2):159-67.

13. Atalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS.,11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genet Mol Res. 2012 Aug 31;11(3):3122-32.

14. Erdağ E, Tüzün E, Uğurel E, Cavuş F, Sehitoğlu E, Giriş M, Vural B, Eraksoy M, Akman-Demir G., Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse. Inflamm Res. 2012 Sep;61(9):927-30.

15. Uz B, Tatonyan SC, Sayitoglu M, Erbilgin Y, Ng OH, Buyukasik Y, Sayinalp N, Aksu S, Goker H, Ozcebe OI, Ozbek U, Haznedaroglu IC.Local hematopoietic renin-angiotensin system in myeloid versus lymphoid hematological neoplastic disorders. J Renin Angiotensin Aldosterone Syst. 2012 Nov 6.

16. Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol. 2012 Nov;10(11):e1001430.

17. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim AS, Yazici Z. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Cardiovasc Diabetol. 2012 Sep 25;11:115.

18. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim AS, Yazıcı Z. Mediastinal adipose tissue expresses a pathogenic profile of 11 β-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease. Cardiovasc Pathol. 2012 Sep 3.

19. EPICURE Consortium; EMINet Consortium, Steffens M, Leu C, Ruppert AK, Zara F, Striano P, Robbiano A, Capovilla G, Tinuper P, Gambardella A, Bianchi A, La Neve A, Crichiutti G, de Kovel CG, Kasteleijn-Nolst Trenité D, de Haan GJ, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Steinhoff BJ, Kleefuß-Lie AA, Kunz WS, Surges R, Elger CE, Muhle H, von Spiczak S, Ostertag P, Helbig I, Stephani U, Møller RS, Hjalgrim H, Dibbens LM, Bellows S, Oliver K, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Guipponi M, Malafosse A, Thomas P, Nabbout R, Baulac S, Leguern E, Guerrero R, Serratosa JM, Reif PS, Rosenow F, Mörzinger M, Feucht M, Zimprich F, Kapser C, Schankin CJ, Suls A, Smets K, De Jonghe P, Jordanova A, Caglayan H, Yapici Z, Yalcin DA, Baykan B, Bebek N, Ozbek U, Gieger C, Wichmann HE, Balschun T, Ellinghaus D, Franke A, Meesters C, Becker T, Wienker TF, Hempelmann A, Schulz H, Rüschendorf F, Leber M, Pauck SM, Trucks H, Toliat MR, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol Genet. 2012 Dec 15;21(24):5359-72.

20. Müge Sayitoğlu, Yücel Erbilgin, Özden Hatırnaz, İnci Yıldız, Tiraje Celkan, Sema Anak, Ömer Devecioğlu, Gönül Aydoğan, Serap Karaman, Nazan Sarper, Çetin Timur, Ümit Üre, Uğur Özbek. Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL). TJH pages 325-333.

21. Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic Alterations in the Members of WNT Pathway in Acute Leukemia. Leuk Lymphoma. 2012 Mar; 53(3): 508-10.

22. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gül A, Remmers EF, Kastner DL. Genome-wide association analysis identifies new susceptibility loci for Behçet’s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013 Jan 6.   

23. Cosan F, Emrence Z, Erbag G, Azakli H, Yilmazer B, Yazici A, Ekmekci SS, Abaci N, Ustek D, Cefle A. The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still’s disease. Rheumatol Int. 2012 Dec 27.

24. Gezer U, Ustek D, Yörüker EE, Cakiris A, Abaci N, Leszinski G, Dalay N, Holdenrieder S. Characterization of H3K9me3- and H4K20me3-associated circulating nucleosomal DNA by high-throughput sequencing in colorectal cancer. Tumour Biol. 2012 Oct 20.

25. Sogutcu E, Emrence Z, Arikan M, Cakiris A, Abaci N, Oner ET, Ustek D, Arga KY. Draft Genome Sequence of Halomonas smyrnensis AAD6T. J Bacteriol. 2012 Oct . 194(20):5690-1.

26. Kara B, Arıkan M, Maraş H, Abacı N, Cakıris A, Ustek D. Whole mitochondrial genome analysis of a family with NARP/MILS caused by m.8993T>C mutation in the MT-ATP6 gene. Mol Genet Metab. 2012 Jul 10.

27. Akyuz F, Besisik F, Ustek D, Ekmekçi C, Uyar A, Pinarbasi B, Demir K, Ozdil S, Kaymakoglu S, Boztas G, Mungan Z, Gul A. Association of the MEFV Gene Variations With Inflammatory Bowel Disease in Turkey. J Clin Gastroenterol. 2012 Jul 17.

28. Ozbek E, Polat EC, Ozcan L, Otunctemur A, Emrence Z, Ustek D. TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.J Obstet Gynaecol Res. 2012 Jul 6.

29. Sirma Ekmekci S, G Ekmekci C, Kandilci A, Gulec C, Akbiyik M, Emrence Z, Abaci N, Karakas Z, Agaoglu L, Unuvar A, Anak S, Devecioglu O, Ustek D, Grosveld G, Ozbek U. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Tumori. 2012 Mar . 98(2):252-6.

30. Ustek D, Sirma S, Gumus E, Arikan M, Cakiris A, Abaci N, Mathew J, Emrence Z, Azakli H, Cosan F, Cakar A, Parlak M, Kursun O. A genome-wide analysis of lentivector integration sites using targeted sequence capture and next generation sequencing technology. Infect Genet Evol. 2012 May 14.

31. Topcuoglu N, Keskin F, Ciftci S, Paltura C, Kulekci M, Ustek D, Kulekci G. Relationship between Oral Anaerobic Bacteria and Otitis Media with Effusion. Int J Med Sci. 2012 . 9(3):256-61.

32. Aruk T, Ustek D, Kursun O. A novel partial sequence alignment tool for finding large deletions. ScientificWorldJournal. 2012. 2012 :694813.

33. Bongiovanni A, Romancino DP, Campos Y, Paterniti G, Qiu X, Moshiach S, Di Felice V, Vergani N, Ustek D, d’Azzo A. Alix is a substrate of the Ozz-E3 ligase, and modulates actin remodeling in skeletal muscle. J Biol Chem. 2012 Feb 13.

34. Gumus E, Kursun O, Sertbas A, Ustek D Application of Canonical Correlation Analysis for Identifying Viral Integration Preferences. Bioinformatics. 2012 Jan 12.

35. Mahmut Parlak, Duran Ustek, Aziz Tanriseven. A novel method for covalent immobilization of dextransucrase. Journal of Molecular Catalysis B: Enzymatic 28 December 2012. 14.

2011 Publications

1. Coban N, Onat A, Guclu-Geyik F, Komurcu-Bayrak E, Sansoy V, Hergenc G, Can G, Erginel-Unaltuna N. Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) -482C>T polymorphism on triglyceride concentration in Turkish adults. Clin Chem Lab Med. 2011 Oct 18.

2. Hatemi AC, Güleç C, Cine N, Vural B, Hatırnaz O, Sayitoğlu M, Oztunç F, Saltık L, Kansız E, Erginel Ünaltuna N. Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism. Anadolu Kardiyol Derg. 2011 Jun;11(4):319-28.

3. Onat A, Erginel-Unaltuna N, Coban N, Ciçek G, Yüksel H. APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: interrelation and roles in predicting type-2 diabetes and coronary disease. Clin Biochem. 2011 Apr;44(5-6):391-6.

4. Komurcu-Bayrak E, Onat A, Yuzbasiogullari B, Mononen N, Laaksonen R, Kähönen M, Hergenc G, Lehtimäki T, Erginel-Unaltuna N. The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks. Metabolism. 2011 May;60(5):655-63.

5. Adas G, Percem A, Adas M, Kemik O, Arikan S, Ustek D, Cakiris A, Abaci N, Kemik AS, Kamali G, Karahan S, Akcakaya A, Karatepe O. VEGF-A and FGF gene therapy accelerate healing of ischemic colonic anastomoses (experimental study). Int J Surg. 2011;9(6):467-71. Epub 2011 May 27.

6. Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K. Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray Cross-Complementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange Frequency in Patients with Chronic Lymphocytic Leukemia. Genet Test Mol Biomarkers. 2011 Nov 22.

7.  Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, Kamali G, Eryasar B, Ustek D. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2011 Jan;396(1):115-26. Epub 2010 Oct 17.

8. Abaci N, Cosan F, Gulec C, Azakli H, Emrence Z, Sirma-Ekmekci S, Cakiris A, Oku B; Ustek D. HYPOXIA INDUCES ERYTHROPOIETIN RECEPTOR EXPRESSION ON K562 CELL LINE BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT AUG:2011: 25(3): 2508-2512   DOI: 10.5504/BBEQ.2011.0061

9. Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B.Pancreas-Specific Deletion of Prox1 Affects Development and Disrupts Homeostasis of the Exocrine Pancreas. Gastroenterology. 2011 Dec 13.

10. Sema Sırma Ekmekci, Cumhur G. Ekmekci, Ayten Kandilci, Çagrı Güleç, Meral Akbıyık, Zeliha Emrence, Neslihan Abacı, Zeynep Karakaş, Leyla Ağaoğlu, Ayşegül Ünüvar, Sema Anak, Ömer Devecioğlu, Duran Ustek, Gerard Grosveld, Uğur Özbek. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Tumori (kabul edildi).

11. Ostergaard M, Nyvold CG, Jovanovic JV, Andersen MT, Kairisto V, Morgan YG, Tobal K, Pallisgaard N, Ozbek U, Pfeifer H, Schnittger S, Grubach L, Larsen JK, Grimwade D, Hokland P. Development of standardized approaches to reporting of minimal residual disease data using a reporting software package designed within the European LeukemiaNet. Leukemia. 2011 Jul;25(7):1168-73. doi: 10.1038/leu.2011.69. Epub 2011 Apr 15.

12. Gormez S, Demirkan A, Atalar F, Caynak B, Erdim R, Sozer V, Gunay D, Akpinar B, Ozbek U, Buyukdevrim AS. Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease. Intern Med. 2011;50(8):805-10. Epub 2011 Apr 15.

13. Saip R, Sen F, Vural B, Ugurel E, Demirkan A, Derin D, Eralp Y, Camlica H, Ustuner Z, Ozbek U. Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients. J BUON. 2011 Apr-Jun;16(2):241-6.

14. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia. Leuk Res. 2011 Aug 1.

15. Burçak Vural, Elif Uğurel, Erdem Tuzun, Murat Kurtuncu, Luigi Zuliani, Filiz  Çavuş, Sema İçöz , Ece Erdağ, Ahmet Gul, Ali O. Gure, Angela Vincent, Uğur Özbek, Mefkure Eraksoy, Gulşen Akman-Demir. Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet’s disease. Journal of Neuroimmunology 239 (2011) 91–97.

16. Yildirim Y., Orhan EK., Iseri SAU., Serdaroglu-Oflazer P., Kara B., Solakoglu, S., Tolun A. A frameshift mutation of ERLIN2 in recessive intellectual disability, motor dysfunction and multiple joint contractures. HUMAN MOLECULAR GENETICS Volume: 20   Issue: 10   Pages: 1886-1892  Published: MAY 15 2011

17. Alessandro Gialluisi, Tommaso Pippucci, Yair Anikster, Ugur Ozbek, Myrna Medlej-Hashim, Andre Me´garbane  and Giovanni Romeo. Estimating the Allele Frequency of Autosomal Recessive Disorders through Mutational Records and Consanguinity: The Homozygosity Index (HI). Annals of Human Genetics (2011) 00,1–9.

18. A. E. Eskazan, T. Soysal, Y. Erbilgin, U. Ozbek, B. Ferhanoglu. Chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutations are resistant to dasatinib: Is that true for all the patients? Leukemia Research, 21 May 2011.

19. Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic Alterations in the Members of WNT Pathway in Acute Leukemia. Leuk Lymphoma. 2011 Sep 9.

2009-2010 Publications

1. Ozsait B, Komurcu-Bayrak E, Levula M, Erginel-Unaltuna N, Kähönen M, Rai M, Lehtimäki T, Laaksonen R., Niemann-Pick type C fibroblasts have a distinct microRNA profile related to lipid metabolism and certain cellular components. Biochem Biophys Res Commun. 2010 Nov 12. [Epub ahead of print]

2. Onat A, Erginel-Unaltuna N, Coban N, Ciçek G, Yüksel H. APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: Interrelation and roles in predicting type-2 diabetes and coronary disease. Clin Biochem. 2010 Dec 23. [Epub ahead of print] PubMed PMID: 21185820.

3. Komurcu-Bayrak E, Onat A, Yuzbasiogullari B, Mononen N, Laaksonen R, Kähönen M, Hergenc G, Lehtimäki T, Erginel-Unaltuna N., The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks., Metabolism. 2010 Aug 17. [Epub ahead of print]PMID: 20723945 [PubMed – as supplied by publisher]Related citations

4. Gözü A, Poda M, Taşkin EI, Turgut H, Erginel-Unaltuna N, Doğruman H, Ozsoy Z., Pretreatment with octreotide modulates iNOS gene expression, mimics surgical delay, and improves flap survival., Ann Plast Surg. 2010 Aug;65(2):245-9.

5. Onat A, Kömürcü-Bayrak E, Can G, Küçükdurmaz Z, Hergenç G, Erginel-Unaltuna N., Apolipoprotein A-I positively associated with diabetes in women independently of apolipoprotein E genotype and apolipoprotein B levels., Nutrition. 2010 Oct;26(10):975-80.

6. Abaci N, Güleç C, Bayrak F, Kömürcü Bayrak E, Kahveci G, Erginel Unaltuna N.The variations of BOP gene in hypertrophic cardiomyopathy., Anadolu Kardiyol Derg. 2010;10(4):303-9.

7. Gurses C, Ekizoglu O, Orhan N, Ustek D, Arican N, Ahishali B, Elmas I, Kucuk M, Bilgic B, Kemikler G, Kalayci R, Karadeniz A, Kaya M. Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia. Brain Res. 2009 Jul 24;1281:71-83. Epub 2009 May 21. PMID: 19464270.

8. Coşan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoğlu F, Saruhan-Direskeneli G, Ustek D, Gül A. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçets disease. Clin Rheumatol. 2009 Dec;28(12):1385-8. Epub 2009 Aug 21. PMID: 19693643.

9. Cosan F, Yazici A, Yılmazer B, Gul A, Ustek D, Cefle A. A novel TNFRSF1 gene mutation in a Turkish family: a report of three cases. Clin Rheumatol. 2010 Jun 10.PMID: 20532935.

10. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, OShea J, Wallace GR, Gadina M, Kastner DL, Gül A. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçets disease. Nat Genet. 2010 Aug;42(8):698-702. 2010 Jul 11. PMID: 20622878.

11. Cosan F, Ustek D, Oku B, Duymaz-Tozkir J, Cakiris A, Abaci N, Ocal L, Aral O, Gül A. Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. Arthritis Rheum. 2010 Nov;62(11):3232-6. doi: 10.1002/art.27683. PMID: 20669279.

12. Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, Kamali G, Eryasar B, Ustek D. Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study). Langenbecks Arch Surg. 2010 Oct 17. PMID: 20953879.

13. Erbilgin Y, Sayitoglu M, Hatirnaz O, Dogru O, Akcay A, Tuysuz G, Celkan T, Aydogan G, Salcioglu Z, Timur C, Yuksel-Soycan L, Ure U , Anak S, Agaogl S, Devecioglu O, Yildiz I, Ozbek U, Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. Disease Markers 28 (2010) 1–8

14. Atalar F, Tevfik Acuner T, Cine N, Oncu F, Yesilbursa D, Ozbek U, Turkcan S.Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study. Behav Brain Funct. 2010 May 28;6(1):27

15. Vural B, Demirkan A, Ugurel E, Kalaylioglu-Wheeler Z, Esen BA, Gure AO, Gül A, Ozbek U. Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behçets disease. Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S67-72.

16. Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK, Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U. Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia. Genet Test Mol Biomarkers. 2009 Oct;13(5):599-602.

17. Baccarani M, Rosti G, Castagnetti F, Haznedaroglu I, Porkka K, Abruzzese E, Alimena G, Ehrencrona H, Hjorth-Hansen H, Kairisto V, Levato L, Martinelli G, Nagler A, Nielsen JL, Ozbek U, Palandri F, Palmieri F, Pane F, Rege-Cambrin G, Russo D, Specchia G, Testoni N, Weiss-Bjerrum O, Saglio G, Simonsson B. A comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of patients with high risk, Philadelphia-positive, chronic myeloid leukaemia: a European LeukemiaNet study. Blood. 2009 May 7;113(19):4497-504

18. Muge Sayitoglu, Ibrahim C. Haznedaroglu, Ozden Hatirnaz, Yucel Erbilgin, Salih Aksu, Ebru Koca, Cafer Adiguzel, Mahmut Bayik, Ibrahim Akalin, Zafer Gülbas, Meltem Akay, Ali Unal, Leylagul Kaynar, Ercument Ovali, Mustafa Yilmaz, Mustafa Yenerel, Simten Dagdas, Gulsum Ozet, Cem Ar, Yildiz Aydin, Teoman Soysal, Barbaros Durgun, Osman Ozcebe, Ajlan Tukun, Osman Ilhan, Ugur Ozbek. Effects of Imatinib Mesylate on the Renin Angiotensin System (RAS) Activity During the Clinical Course of Chronic Myleoid Leukemia (CML). The Journal of International Medical Research, 2009; 37:1018-1028.

19. Evrim KB, Nihan EU, Altan O, Bilge O, Carita E, Mikko H, Nina M, Reijo L, Gulay H, Terho L. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. Atherosclerosis. 2009 Apr 5.

20. Onat A, Hergenç G, Agirbaşli M, Kaya Z, Can G, Unaltuna NE. Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking. Clin Chem Lab Med. 2009;47(2):208-15.

21. Oksala N, Levula M, Airla N, Pelto-Huikko M, Ortiz RM, Järvinen O, Salenius JP, Ozsait B, Komurcu-Bayrak E, Erginel-Unaltuna N, Huovila AP, Kytömäki L, Soini JT, Kähönen M, Karhunen PJ, Laaksonen R, Lehtimäki T.ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries-Tampere vascular study. Ann Med. 2009;41(4):279-90

22. Coşan F, Oku B, Cakiris A, Duymaz-Tozkir J, Mercanoğlu F, Saruhan-Direskeneli G, Ustek D, Gül A. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçets disease. Clin Rheumatol. 2009 Dec;28(12):1385-8.

23. Gurses C, Ekizoglu O, Orhan N, Ustek D, Arican N, Ahishali B, Elmas I, Kucuk M, Bilgic B, Kemikler G, Kalayci R, Karadeniz A, Kaya M. Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia. Brain Res. 2009 Jul 24;1281:71-83.

24. Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK, Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U, “Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia”, Genet Test Mol Biomarkers 2009, 13:599-602.

2007-2008 Publications

1. Chtcheglova L.A, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdofer P. Localization of the Ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging. European Journal of Physiology. Eur J Physiol 2008 456:247–254

2. Öztürk M., Üstek D., Akbas F, Kösem M., Abaci N., Alagöl F., Öztürk G., Kotan Ç. The presence of erythropoietin receptor in parathyroid cells. J Endocrinol Invest. J Endocrinol Invest. 2007 Dec; 30(11): RC35-7

3. Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS. Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008 Nov-Dec;17(6):392-8.

4. Ustuner Z, Saip P, Yasasever V, Vural B, Yazar A, Bal C, Ozturk B, Ozbek U, Topuz E. Prognostic and predictive value of vascular endothelial growth factor and its soluble receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients. Med Oncol. 2008 ;25(4):394-9.

5. Chtcheglova LA, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdorfer P. Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging. Pflugers Arch. 2008 Apr;456(1):247-54.

6. Ince AT, Hatırnaz O, Ovünc O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S, IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2008 Jun;53(6):1683-92.

7. Sayitoğlu M, Ar MC, Hatırnaz O, Ongören S, Ure U, Başlar Z, Sırma,S Aydın Y, Özbek U, Ferhanoğlu B. Minimal Residual Disease (MRD) Detection with Translocations and T-Cell Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic Leukaemia Patients: A Pilot Study. Turkish Journal of Hematology. 2008 25 (3): 124-132.

8. Ustek D, Sırma S, Cakiris A, Cosan F, Oku B, Ozbek U. Cloning of chimerical translocations as positive control for molecular genetic diagnosis of leukemia. Turkish Journal of Hematology. 2008 25 (1):20-23

9. Pinar Kadioglu, Gokhan Oral, Muge Sayitoglu, Nevin Erensoy, Berna Senel, Nurperi Gazioglu, Aydin Sav, Gursel Cetin, Ugur Ozbek. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary (2008) 11:29–35.

10. Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Palmen J, Guclu F, Can G, Erginel-Unaltuna N., Gender-modulated impact of apolipoprotein A5 gene (APOA5) -1131T>C and c.56C>G polymorphisms on lipids, dyslipidemia and metabolic syndrome in Turkish adults., Clin Chem Lab Med. 2008;46(6):778-84.

11. Jia P, Zhang C, Huang XP, Poda M, Akbas F, Lemanski SL, Erginel-Unaltuna N, Lemanski LF., A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum., J Biomed Sci. 2008 Nov;15(6):789-99. Epub 2008 Jun 19.

12. Ozsait B, Kömürcü Bayrak E, Poda M, Can G, Hergenç G, Onat A, Humphries SE, Erginel Unaltuna N., CETP TaqIB polymorphism in Turkish adults: association with dyslipidemia and metabolic syndrome., Anadolu Kardiyol Derg. 2008 Oct;8(5):324-30.

13. Okumus G, Kiyan E, Arseven O, Tabak L, Diz-Kucukkaya R, Unlucerci Y, Abaci N, Unaltuna NE, Issever H.Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism., Clin Appl Thromb Hemost. 2008 Apr;14(2):168-73.

14. Sen F, Demirturk M, Abaci N, Golcuk E, Oflaz H, Elitok A, Kutluturk F, Issever H, Unaltuna NE, Ozbey NC, Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopituitary GH-deficient adult patients.,Eur J Endocrinol. 2008 May;158(5):615-22.

15. Deymeer F, Serdaroglu P, Parman Y, Poda M, Natural history of SMA IIIb:Muscle strength decreases in a predictable sequence and magnitude. Neurology, 2008;71:644–649

16. Ustek D, Ekmekçi C, Oku B, Cosan F, Cakiris A, Abaci N, Çelik S, Kamalı S, Hatemi G, Kasapçopur O, Özdogan H, Gül A. The MEFV Gene 3’-UTR Alu Repeat Polymorphisms in Patients with Familial Mediterranean Fever. Clin Exp Rheumatol. 2008, Jul-Aug;26(4 Suppl 50): S72-76

17. Sen F, Demirturk M, Abaci N, Golcuk E, Oflaz H, Elitok A, Kutluturk F, Issever H, Erginel-Unaltuna N and Ozbey N. Endothelial Nitric Oxide Synthase Intron 4a/b Polymorphism and Early Atherosclerotic Changes in Hypopituitary Growth Hormone Deficient Adult Patients European Journal of Endocrinology, 2008 May;158(5):615-22.

18. Kaya M, Gurses C, Kalayci R, Ekizoglu O, Ahishali B, Orhan N, Oku B, Arican N, Ustek D, Bilgic B, Elmas I, Kucuk M, Kemikler G. Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. Brain Res. 2008 May 7;1208:181-91.

19. Ustek D, Ekmekci CG, Selçukbiricik F, Cakiris A, Oku B, Vural B, Yanar H, Taviloglu K, Ozbek U, Gül A. Association between reduced levels of MEFV messenger RNA in peripheral blood leukocytes and acute inflammation. Arthritis Rheum. 2007 56(1): 345-50.

20. Thomas NS, Wiseman K, Spurlock G, MacDonald M, Ustek D, Upadhyaya M. A large patient study confirming that facioscapulohumeral muscular dystrophy disease expression is almost exclusively associated with an FSHD locus located on a 4qA-defined 4qter subtelomere. J Med Genet. 2007 44(3): 215-8.

21. Okumus G., Kiyan E., Arseven O., Tabak L., Bayrak EK., Unaltuna NE., Issever H. Platelet Glycoprotein Ia 807C/T And 873G/A Polymorphisms in Patients with Venous Thromboembolism. Clin Appl Thromb Hemost. 2007 13(1):101-3.

22. Komurcu-Bayrak E, Onat A, Poda M, Humphries SE, Acharya J, Hergenc G, Coban N, Can G, Erginel-Unaltuna N. The S447X Variant of Lipoprotein Lipase Gene is Associated with Metabolic Syndrome and Lipid Levels Among Turks. Clin Chim Acta. 2007 383(1-2):110-5.

23. Kadioglu P., Oral G., Sayitoglu M., Erensoy N., Senel B:, Gazioglu N., Sav A., Cetin G., Ozbek U. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary. 2007 Aug 17;

24. Ince AT, Hatırnaz O, Ovünç O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S, IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2007 Nov 3;

25. Yönal O, Hatirnaz O, Akyüz F, Ozbek U, Demir K, Kaymakoglu S, Okten A, Mungan Z. HFE gene mutation, chronic liver disease, and iron overload In Turkey. Dig Dis Sci. 2007 Nov;52(11):3298-302.

26. Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, Ferhanoğlu B, Ozçelik T, Ozbek U. The SOCS-1 gene methylation in chronic myeloid leukemia patients. Am J Hematol. 2007 Aug;82(8):729-30.

27. Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66.

28. Nurperi Gazioglu, Nevin Erensoy, Pinar Kadioglu, Muge Aydin Sayitoglu, Ismail Hakki Ersoy, Ozden Hatirnaz, Bunyamin Kisacik, Buge Oz, Mehmet Sar, Ugur Ozbek, Nejat Ciplak, Penbe Cagatay, Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas, Med Sci Monit, 2007,13(10): CR457-463.

2005-2006 Publications

1. Bayrak F., Komurcu-Bayrak E., Mutlu B, Kahveci G., Basaran Y., Erginel-Unaltuna N. Ventricular Pre-Excitation and Cardiac Hypertrophy Mimicking Hypertrophic Cardiomyopathy in a Turkish Family with a Novel PRKAG2 Mutation. Eur J Heart Fail. 2006 8: 712-715.

2. Aydın M., Hatirnaz O., Erensoy N., Ozbek U. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1 and GSTM1 Genes in the Susceptibility to Acute Leukemias. Am J Hem. Mar., 2006,81(3):162-70.

3. Müge Aydın-Sayioğlu, Inci Yıldız, Ozden Hatırnaz, Ugur Özbek Common Cytochrome p4503A (CYP3A4 and CYP3A5) and Thiopurine S-Methyl Transferase (TPMT) Polymorphisms In Turkish Population; Turkish Journal of Medıcal Sciences, 2006: 36 ,11-15.

4. Vural B, Chen L-C, Saip P, Chen Y-T, Ustuner Z, Gonen M, Jager E, Simpson AJG, Old LJ, Ozbek U, Gure AO, Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish SCLC patients and their correlation with clinical parameters, Cancer, 2005,103: 2575-83.

5. Junfeng Wang, Gamze Kilic, Muge Aydin, Zoe Burke, Guillermo Oliver, Beatriz Sosa-Pineda “Prox1 activity controls pancreas morphogenesis and participates in the production of “secondary transition” pancreatic endocrine cells. Dev.Biol., 2005: 286(1):182-94. 2003-

2003-2004 Publications

1. Zhang C, Meng F, Huang XP, Zajdel R, Lemanski SL, Foster D, Erginel-Unaltuna N, Dube DK, Lemanski LF. Downregulation of N1 gene expression inhibits the initial heartbeating and heart development in axolotls. Tissue Cell. 2004 36(1):71-81.

2. Frei K, Lucas T, Ramsebner R, Schofer C, Baumgartner WD, Weipoltshammer K, Erginel-Unaltuna N, Wachtler FJ, Kirschhofer K. A novel connexin 26 mutation associated with autosomal recessive sensorineural deafness. Audiol Neurootol. 2004 9(1):47-50.

3. Tukel T, Shalata A, Present D, Rachmilewitz D, Mayer L, Grant D, Risch N, Desnick RJ. Crohn Disease: Frequency and Nature of CARD15 Mutations in Ashkenazi and Sephardi/Oriental Jewish Families. Am J Hum Genet. 2004 Am J Hum Genet.

4. Muge Aydin, Ozden Hatirnaz , Nevin Erensoy , Ugur Ozbek; CYP2D6 and CYP1A1 mutations in the Turkish Population. Cell Biochem Funct , 2004:22: 1-3.

5. Yildiz P, Oflaz H, Cine N, Erginel-Unaltuna N, Erzengin F, Yilmaz V. Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD. Respir Med. 2003 97(12):1282-8.

6. Yildiz A, Yazici H, Cine N, Kazancioglu R, Akkaya V, Sever MS, Ark E, Erginel-Unaltuna N. Angiotensin converting enzyme gene polymorphism and development of post-transplant erythrocytosis. J Nephrol. 2003 16(3):399-403.

7. Duymaz-Tozkir J, Gul A, Uyar FA, Ozbek U, Saruhan-Direskeneli G. Tumour necrosis factor-alpha gene promoter region -308 and -376 G–>A polymorphisms in Behcets disease. Clin Exp Rheumatol. 2003 Clin Exp Rheumatol.

8. Kalayoglu-Besisik S, Caliskan Y, Sargin D, Gurses N, Ozbek U. Methylenetetrahydrofolate reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell transplantation. Transplantation. 2003 76(12):1775-7.

9. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U. Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003 35(5):454-9.

10. Gutierrez MI, Siraj AK, Bhargava M, Ozbek U, Banavali S, Chaudhary MA, El Solh H, Bhatia K. Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. Leukemia. 2003 17(9):1845-50.

11. Boylu-Akyerli CB, Ozbek U, Aydin-Sayitoglu M, Sirma S, Ozcelik T.Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol. 2003 129(10):604-5.

12. Savli H, Karadenizli A, Kolayli F, Gundes S, Ozbek U, Vahaboglu H. Expression stability of six housekeeping genes: A proposal for resistance gene quantification studies of Pseudomonas aeruginosa by real-time quantitative RT-PCR.J. J Med Microbiol. 2003 52(Pt 5):403-8.

13. Ozbek U, Sirma S, Agaoglu L, Yuksel L, Anak S, Yildiz I, Devecioglu O, Timur C, Meral A, Gedikoglu G. Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey. J Pediatr Hematol Oncol. 2003 25(3):204-8.

14. Onay UV, Kavakli K, Kilinc Y, Gurgey A, Aktuglu G, Kemahli S, Ozbek U, Caglayan SH. Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations. Br J Haematol. 2003 120(4):656-9.

15. Erginel-Unaltuna N, Akbas F. Improved method for molecular diagnosis of myotonic dystrophy type 1 (DM1). J Clin Lab Anal. 2003 18(1):50-4.

16. Akbas F, Erginel-Unaltuna N. DNA testing for Huntington disease in the Turkish population. Eur Neurol. 2003 50(1):20-4.

2001-2002 Publications

1. Komurcu E. and Erginel-Unaltuna N. Frequency of Platelet Glycoprotein Ia 807C/T and 873G/A Polymorphisms in Turkey. Am. J. Hemat. 200269, 1: 83-84.

2. Yıldız A., Yazıcı H., Cıne N., Akkaya V., Kayacan S.M., Sever M.S., Erginel-Unaltuna N. The effect of angiotensin converting enzyme gene polymorphism on chronic allograft dysfunction in living donor renal recipients. Clin Transplant. 2002Jun; 16 (3): 173-9.

3. Cine N., Hatemi A. C., and Erginel-Unaltuna N. Association of a polymorphism of the ecNOS gene with Myocardial Infarction in a subgroup Turkish MI patients Clin Genet. 2002 Jan; 61 (1):66-70.

4. Algun E, Abaci N, Kosem M, Kotan C, Koseoglu B, Boztepe H, Sekeroglu R, Aslan H, Topal C, Ayakta H, Uygan I, Alagol F, Erginel-Unaltuna N, Aksoy H. Clinical characteristics and genetic screening of an extended family with MEN2A. J Endocrinol Invest. 2002Jul-Aug;25(7):603-8.

5. Aşcıoğlu F., Akyüz F., Çetinkaya, U., Yılmaz, S., Koluaçık, S., Vural, B., Özbek, U., Turkish population data on nine short tandem repeat loci: HumCSF1PO, HumTHO1, HumTPOX, HumFES/FPS, HumF13B, HumVWA, D3S1358, D7S820, D16S539, Forensic Science International 2002, 126:252-3.

6. Akbas F., Serdaroglu P., Deymeer F., Aysal F., and Erginel-Unaltuna N. Molecular and clinical study of two myotonic dystrophy patients with homozygosity J. Med. Genet. 200138 (11): E40

7. Erginel-Unaltuna N., Peoch,K., Komurcu E., Acuner T., Issever H., Laplanche JL.. Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease. European Journal of Human Genetics. 20019, 965-968.

8. Tüysüz B., Dursun A., Kutlu T., Sökucu S., Çine N., Suo lu Ö., Erkan T., Erginel-Unaltuna N., Tümay G. HLA-DQ alleles in patients with celiac disease in Turkey. Tissue Antigens 2001 Jun; 57(6):540-542.


National

    Behçet Hastalarında SWAP70 Antikorunun İncelenmesi, Ugurel E, Karabulut A, Gül A, Güre AO, Erkingül S, Tuzun E, Ozbek U, Vural B, DETAE e-dergi, Yıl 2, Cilt 2, Sayı 4, Sayfa 22-29, 2012
  1. Ali Osman Güre, Burçak Vural, Uğur Özbek, Nalan Demir Fırat, İsmail Savaş, Akciğer Kanserinin Teşhis, Tedavi ve Takibinde Yeni Bir Parametre Olarak Anti-Tümör Antikorların Önemi, Plevra Bülteni, Ocak 2012 (Türk Toraks Derneği, online bülten)
  2. Akut lösemi hücre serilerinde beta-katenin sirna uygulamaları, Özden Hatırnaz Ng1, PhD, Yücel Erbilgin1, MSc, Esin Aktaş2, Doç. Dr., Günnur Deniz2, Prof. Dr., Uğur Özbek1, Prof. Dr., Müge Sayitoğlu1*, Doç. Dr., 2012, Deneysel Tıp Dergisi, Cilt 2, Sayı 3, 16-22
  3. Poda M. Kalıtsal Dislipidemi Fenotipleri ve Genetik İlişkiler Üzerine Derleme,Deneysel Tıp Araştırma Enstitüsü Dergisi,1 (2), 14-19, 2011.
  4. Ustek D, Abaci N, Sirma S, Çakiris A. T-Yeni Nesil DNA Dizileme Derleme,Deneysel Tıp Araştırma Enstitüsü Dergisi,1 (1), 11-18, 2011.
  5. Evrim Kömürcü-Bayrak, Nihan Erginel-Ünaltuna. Gen anlatımı analiz yöntemlerine genel bakış. Deneysel Tıp Dergisi, 2011: 1(2); 28-35.
  6. Erbilgin Y, Eskazan AE, Catal S, Hatirnaz O, Soysal T, Ozbek U. ABL Gene Kinase Domain Mutation Scanning by Denaturing High Performance Liquid Chromatography Sequencing Method. Turkish Journal of Hematology. Vol 28 Issue 2 June 2011 97-102.
  7. Yavuz EN, Demirkan A, Moen S, Ozdemir O, Catal S, Bebek N, Ozbek U, Baykan B. Investigation of the Relationship Between Clinical and EEG Findings of Photosensitive Epilepsy and GABA Receptor Alpha 1 Subunit (GABRA1) Gene Mutations. Archives of Neuropsychiatry 2011; 48: 39-43.
  8. Erbilgin Y., Hatırnaz Ng Ö., Sayitoğlu M., Söderberg O., Özbek U.. ß-Katenin ve Axin2 proteinleri etkileşimlerinin “Proksimiti LigasyonAssay (Yakınsal Bağlanma Tespiti)” ile görüntülenmesi. Deneysel Tıp Dergisi, 1 (2), 24-27, 2011
  9. Erbilgin Y, Eskazan AE, Catal S, Hatirnaz O, Soysal T, Ozbek U. ABL Gene Kinase Domain Mutation Scanning by Denaturing High Performance Liquid Chromatography Sequencing Method. Turkish Journal of Hematology. 2010 in press.
  10. Müge Aydın Sayitoğlu, Uğur Özbek, Kronik Miyeloid Lösemide Moleküler Tanı ve Takip, Türkiye Klinikleri, Journal of Hematology-Oncology. 2(2):48-53, Ekim (2009).
  11. Duran Üstek, Sema Sırma, Aris Çakiris, Fulya Coşan, Başar Oku, Uğur Özbek, Cloning of chimerical translocations as positive control for molecular genetic diagnosis of leukemia. Turk J Hematol 2008; 25:20-23
  12. Bayrak F, Kömürcü-Bayrak E, Mutlu B, Kahveci G, Erginel-Ünaltuna N. Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. Turk Kardiyol Dern Ars. 2008 36(2):90-5.
  13. Müge Aydın-Sayitoğlu, Sema Sırma, Uğur Özbek Akut Lösemilerde Moleküler Genetik Klinikleri Journal of Medical Sciences, Lösemiler özel sayısı 2007 3(2)
  14. Müge Aydın-Sayitoğlu Kanser Tedavisine Farmakogenetik Yaklaşım Türkiye Klinikleri Journal of Medical Sciences 2007
  15. Müge Aydın-Sayitoglu, M. Cem Ar, Özden Hatırnaz, Şeniz Öngören, Ümit Üre, Zafer Başlar, Sema Sırma, Yıldız Aydın, Uğur Özbek, Burhan Ferhanoğlu Minimal Residual Disease (MRD) Detection with Translocations and T-Cell Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic Leukaemia Patients: A Pilot Study Turkish Journal of Hematology
  16. Yönal O, Hatirnaz O, Akyüz F, Köroğlu G, Ozbek U, Cefle K, Mungan Definition of C282Y mutation in a hereditary hemochromatosis family from Turkey. Turk J Gastroenterol 2007 18(1):53-57.
  17. Olcay A, Nişanci Y, Ekmekçi CG, Ozbek U, Sezer M, Umman B, Buğra Z. Angiotensinogen M235T polymorphism and left ventricular indices in treated hypertensive patients with normal coronary arteries. Anadolu Kardiyol Derg. 2007 7(3):257-61.
  18. Komurcu E., Issever H., Erginel-Unaltuna N. Glycoprotein Ia 807TT/873AA Genotype is not Associated With Myocardial Infarction. Anadolu Kardiyoloji Dergisi 2005 5 (3): 182–186.
  19. Demirkan, A., Vural, B., Üstüner, Z., Uygun, K., Öztürk-Açıkalın, B., Derin, D., Saip, P., Özbek, U., “CYP1A1, GSTM1 and NQO1 gene polymorphisms: Genetic risk factors for small cell lung cancer”, Turkish Journal of Cancer 2005, 35: 171-6 .
  20. Duran Ustek, Sema Sırma, Aris Cakiris, Fulya Cosan, Basar Oku, Ugur Ozbek Lösemilerin Moleküler Genetik Teşhisinde Kullanılmak Üzere Tarnslokasyonların Pozitif Standart Amaçlı Olarak Klonlanması Turkish J Hematology
  21. Kömürcü E., Koç-Bebek A., Tüysüz B., Bebek N., Poda M., Özdemir C., Madazlı R., Erginel-Ünaltuna N., Özbek U. Spinal Müsküler Atrofi (SMA) Hastalığının Prenatal Dönemde Moleküler Tanısı. Moleküler Tanı Dergisi 2004 1: 9–12.
  22. Savli H, Sirma S, Aktan M, Dinçol G, Özbek U. Quantification of all-trans-retinoic acid dependent expression of CXCR4 gene in acute ptomyelocytic leukaemia. Turk J Haematol 2003 20(3): 153-159.
  23. Savli H, Sirma S, Özbek U. Qantification of the FLI-1 gene expression by real-time quantitative RT-PCR. Turk J Med Sci 2003 33:21-25
  24. Vural, B., Atlıoğlu, E., Ozbek, U., Büyükdevrim, S., Kolusayın, O., Ozcelik, T., Ülkemizde DNA analizi (HLADQA1, LDLR, GYPA, HBGG ve GC lokusları)”, Adli Tıp Bülteni 2002, 7: 5-13.
  25. Sarper N, Özbek U, Agaoğlu L, Özgen Ü, Kandilci A, Sırma S, Anak S, Yalman N, Eryılmaz E, Devecioğlu Ö, Gedikoğlu G. Detection of BCR-ABL transcripts by reverse transcriptase polymerase chain reaction in pediatric acute lymphoblastic leukemia: Incidence and clinical features. Turk J Haematol. 2000 17(4):197-206
  26. Özgen Ü, Anak S, Özbek U, Sarper S, Eryılmaz E, Ağaoğlu L, Devecioğlu L, Yalman N, Gedikoglu G. Prognostic significance of Wilms tumor 1 gene in childhood acute lymphoblastic leukemia. Turk J Haematol. 2000 17(4):183-188
  27. Günay A, Öztürk A, Budak T, Özbek U, Üskent N. Activated protein C resistance in polycythemia vera Turk J Haematol 2000 18(3):157-164
  28. Demirel Ş, Çine N, Tükek T, Sözen AB, Erk O, Erginel-Ünaltuna N, Edirne S. Türk popülasyonunda endotelyal konstitütif nitrik oksid sentaz gen polimorfizmi. Türk Kardiyol Dern Arş. 2001 29:637-641
  29. Hatemi AC., Cine N, Tabak L., Kıyan E., Erelel M., Çuhadaroğlu Ç., Kıyan A. Angiotensin Converting Enzyme 1Gene Polymorphism in Patient with Sarcoidosis Turkish Respiratory Journal 2001 2(2): 35-38.
  30. Demirel Ş., Çine N., Tükek T., SözenA.B., Erk O., Erginel-Ünaltuna N., Dilmener M., Erdine Sarch. Endothelial Constitutive Nitric Oxide Synthase Gene Polymorphism in the Turkish Population. Turk. Soc. Cardiol. 2001 29: 637-641.

  • 1967 – 2017: 50th Anniversary of the ESHG : The European Human Genetics Conference 2017, Copenhagen, Denmark, May 27-30, 2017
  • The American Society Of Human Genetics : 2017 Annual Meeting Orlando, USA , Oct. 17-21
  • 6th International Conference on Tissue Engineering & Regenerative Medicine, Baltimore, USA, Aug 20-22, 2017
  • 8th World Congress and Expo on Cell & Stem Cell Research, Orland, USA, March 20-22, 2017
  • 15th World Congress on Biotechnology and Biotech Industries Meet, Rome, Italy, March 20-21, 2017
  • 2nd International Conference on Genetic Counselling and Genomic Medicine , Beijing, China, July 10-12, 2017
  • International Conference on Clinical and Molecular Genetics, Las Vegas, USA, April 24-26, 2017
  • 2nd World Congress on Human Genetics, Chicago, USA, July 24-26, 2017
  • 9th International Conference on Genomics and Pharmacogenomics, London, UK, June15-16, 2017
  • 16th Global Diabetes Conference & Medicare Expo, March 22-23 2017, Rome Italy
  • 12th Asia Pacific Diabetes Conference and Expo, July 24-25 2017, Melbourne, Australia
  • ATTD 2017 – Advanced Technologies & Treatments for Diabetes, February 15-18 2017, Paris, France
  • Plant Genomics and Gene Editing Congress Conference Asia April 10-11, 2017 Hong Kong.
  • 28th Annual Lorne Genomics Conference 2017 February 12-14, 2017 Mantra Lorne, Victoria, Australia.
  • 29th Fungal Genetics conference March 14-19, 2017 Pacific Grove, CA

9th International Conference on Genomics and Pharmacogenomics July 13-14, 2017 Chicago, USA

2012

-Filiz Güçlü-Geyik, 28. Ulusal Kardiyoloji Kongresi, En İyi Üçüncü Sözlü Bildiri

2010-2011

-Feyza Nur Tuncer, Türkiye Diyabet Vakfı 2011 Bilimsel Araştırma Ödülü

-Feyza Nur Tuncer, European Society of Human Genetics Conference (ESHG) 2011 Bursu

-Feyza Nur Tuncer, “MPN&MPNr-EuroNet Second Training School Molecular Diagnosis of Congenital Erythrocytosis theory, practice” kursu katılım bursu

-Evrim Kömürcü-Bayrak, 27. Ulusal Kardiyoloji Kongresi, En İyi Üçüncü Sözlü Bildiri

2009-2010

-Sibel A. Uğur İşeri, Tüm genom bağlantı analizi ve aday gen incelemesi ile otozomal çekinik İJE’de genetik faktörlerin araştırılması projesi için BAD-Boehringer-Ingelheim Proje Desteği

-Nihan Erginel-Ünaltuna,26. Ulusal Kardiyoloji Kongresi En iyi ikinci sözlü bildiri ödülü (2010).

-Neslihan Çoban, XXVI. Ulusal Kardiyoloji Kongresi En İyi Üçüncü Sözlü Bildiri Ödülü (2009)

-Sinem Özdemirli, 35. Türk Hematoloji Kongresi, 2009, Türk Hematoloji Derneği Genç katılımcı Ödülü, (2009)

-Elif Uğurel, 45. Ulusal Nöroloji kongresi, 2009, Sözlü sunum dalında ikincilik ödülü (2009)

-Yücel Erbilgin, 35. Ulusal Hematoloji Kongresi, 6-9 Ekim 2009, Antalya, Türkiye. Klinik Laboratuvar Ödülü ve Genç Katılımcı Ödülü (2009)

 

2007-2008

-Ozden Hatirnaz, 33rd Annual Meeting of Turkish Society of Hematology, 16-20 October 2007, Antalya, Turkey, Bayer-Shering Pharma, Lymphoproliferative Diseases, Sözlü Sunum Birincilik Ödülü, (2007)

-Yücel Erbilgin,33. Ulusal Hematoloji Kongresi, 16-19 Ekim 2007, Ankara, Türkiye. Klinik Laboratuvar Ödülü. (2007)

-Yücel Erbilgin, 34. Ulusal Hematoloji Kongresi, 8-12 Ekim 2008, İzmir, Türkiye. Genç Katılımcı Ödülü. (2007)

-Burçak Vural, XVII. Ulusal Kanser Kongresi, 19-24. Nisan. 2007, Antalya Türkiye Sözlü Bildiri Birincilik Ödülü (2007)

-Burçak Vural, RAED Romatoloji Ödülü 2007, ikincilik araştırma ödülü (2007) -Sinem Özdemirli, 34. Türk Hematoloji Kongresi, 2008, Türk Hematoloji Derneği Genç katılımcı Ödülü, (2007)

-Evrim Kömürcü-Bayrak, VIII. Ulusal Tıbbi Genetik Kongresi Genetik Epidemiyoloji Dalında Poster Birincilik Ödülü (2008)

 

2005-2006

-Burçak Vural, Türk Kanser Araştırma ve Savaş Kurumu, 2005, Birincilik çalışma ödülü (2005)

-Evrim Kömürcü-Bayrak, XXII. Ulusal Kardiyoloji Kongresi En İyi Birinci Sözlü Bildiri (2006)

-Yücel Erbilgin,32. Ulusal Hematoloji Kongresi, 8-12 Kasım 2006, Antalya, Türkiye. Genç Katılımcı Ödülü. (2006)

-Burçak Vural, 12th International Conference on Behcets Disease, September 20-23, 2006, Lisbon, Portugal. Sözlü Bildiri Birincilik Ödülü. (2006)

-Burçak Vural, VII.Ulusal Prenatal Tanı ve Tıbbi Genetik Kongresi, Kayseri, 17-20 Mayıs 2006, Moleküler Genetik Alanında Poster Birincilik Ödülü (2006)

-Burçak Vural,Prof. Dr. Meliha Terzioğlu Ödülü, İstanbul Üniversitesi, 2006

 

2003-2004

-Ozden Hatirnaz, 30th Annual Meeting of Turkish Society of Hematology, 10-14 October 2003, Istanbul, Türkiye. Genç Katılımcı Ödülü (2003)

-Ozden Hatirnaz, 30th Annual Meeting of Turkish Society of Hematology, 10-14 October 2003, Istanbul, Türkiye. THD Bildiri Ödülü (2003)

-Ozden Hatirnaz, XXX. Ulusal Hematoloji Kongresi, 10-14 Ekim 2003, İstanbul, Türkiye, Genç Katılımcı Ödülü. (2003) -Ozden Hatirnaz, 31st Annulal Meeting of Turkish Society of Hematology, September 23-28,2004, Antalya, Türkiye. Genç Katılımcı Ödülü, (2004)

-Evrim Kömürcü-Bayrak, XX. Ulusal Kardiyoloji Kongresi En Yüksek Puanlı Bildiri (2004)

-Evrim Kömürcü-Bayrak, VI. Prenatal Tanı ve Ulusal Tıbbi Genetik Kongresi (2004)

-Burçak Vural, 31. Ulusal Hematoloji Kongresi, Antalya, Türkiye, 2004, Genç Araştırmacı ödülü, THD ödülü (2004)

 

2000-2002

-Uğur Özbek, İ.Ü. Araştırma Fonu Başarılı Araştırıcı Belgesi (2000)

-Burçak Vural, İ.Ü. Araştırma Fonu Başarılı Araştırıcı Belgesi (2000)

-Nihan Erginel-Ünaltuna, İ.Ü. Araştırma Fonu Başarılı Araştırıcı Belgesi (2001)

-Uğur Özbek, İ.Ü. Araştırma Fonu Başarılı Araştırıcı Belgesi (2001)

-Sema SırmaXXIX. Ulusal Hematoloji Kongresi Genç Katılımcı Ödülü (2002)

-Müge Aydın-Saitoğlu XXIX. Ulusal Hematoloji Kongresi Genç Katılımcı Ödülü (2002)

-Müge Aydın-Saitoğlu XXIX. Ulusal Hematoloji Kongresi Pharmacia Özel

-Evrim Kömürcü-Bayrak, V. Ulusal Prenatal Tanı ve Tıbbi Genetik Kongresi Moleküler Genetik Poster Başarı Ödülü (2002)

-Ozden Hatirnaz,29th Annual Meeting of Turkish Society of Hematology, October 25-28 2002, Antalya, Türkiye Pharmacia Özel Ödülü, (2002)

-Ozden Hatirnaz, XXIX Ulusal Hematoloji Kongresi; Ekim 25-28 2002 Kemer,Antalya Genç Katılımcı Ödülü. İkincilik Ödülü (2002)

Contact Persons

Research Assistant Neslihan Çoban, Ph.D.

neslihancoban@yahoo.com

Assistant Professor Feyza Nur Tuncer-Kılınç

ftuncer@istanbul.edu.tr

Biologist Ferda Paçal, Ph.D.

ferda.pacal@istanbul.edu.tr

 

İstanbul Üniversitesi Aziz Sancar Deneysel Tıp Araştırma Enstitüsü Genetik Anabilim Dalı Vakıf Gureba Cad 34093, Çapa, İstanbul Tel:(0212) 414.20.00 / 33316-19-55 Fax:(0212) 532.41.71